Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Matzanke, B.F. et al.

Matzanke, Böhnke, Möllmann, Reissbrodt, Schünemann, Trautwein,

Iron uptake and intracellular metal transfer in mycobacteria mediated by xenosiderophores.

Growth promotion was tested using M. smegmatis wild type strain, an exochelin-deficient mutant, and M. fortuitum employing a broad variety of xenosiderophores including hydroxamates, catecholates and alpha-hydroxy carboxylic acids. The experiments revealed that utilization of siderophore-bound iron is substrate specific suggesting high-affinity siderophore receptor and transport systems. Concentration-dependent uptake of a selected xenosiderophore (fericrocin) in M. smegmatis showed saturation kinetics and uptake was inhibited by respiratory poisons. In situ MÃ¶ssbauer spectroscopy of ferricrocin uptake in M. smegmatis indicated rapid intracellular reductive removal of the metal excluding intracellular ferricrocin accumulation. The ultimate intracellular iron pool is represented by a compound (delta = 0.43 mm s-1, delta EQ = 1.03 mm s-1) which has also been found in many other microorganisms and does not represent a bacterioferritin, cytochrome or iron-sulfur cluster. By contrast, iron uptake via citrate-a compound exhibiting a very low complex stability constant-involves ligand exchange with mycobactin. Mycobactin has merely a transient role. The ultimate storage compound is an E. coli-type bacterioferritin, in which over 90% of cellular iron is located.[1]

References

Iron uptake and intracellular metal transfer in mycobacteria mediated by xenosiderophores. Matzanke, B.F., Böhnke, R., Möllmann, U., Reissbrodt, R., Schünemann, V., Trautwein, A.X. Biometals (1997) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.