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Aura, J. et al.

Aura, Sirviö, Riekkinen,

Methoctramine moderately improves memory but pirenzepine disrupts performance in delayed non-matching to position test.

The present study was designed to investigate the effect of i.c.v. administration of various muscarinic receptor antagonists in rats on memory performance in delayed non-matching to position test. The drugs chosen were the non-selective antagonist scopolamine (3 and 10 micrograms), the muscarinic M1 receptor-selective antagonist pirenzepine (10 and 30 micrograms) and the muscarinic M2 receptor-selective antagonist methoctramine (2, 5 and 20 micrograms). Scopolamine delay-independently decreased % correct choices and reduced motor activity. Pirenzepine also delay-independently decreased % correct choices. In contrast, methoctramine 2 micrograms, but not at 5 or 20 micrograms, improved slightly, but significantly, % correct performance delay-dependently. The present data suggests that the decrease in activation of inhibitory muscarinic M2 autoreceptors induced by methoctramine produces a specific improvement of short-term memory at long forgetting delays.[1]

References

Methoctramine moderately improves memory but pirenzepine disrupts performance in delayed non-matching to position test. Aura, J., Sirviö, J., Riekkinen, P. Eur. J. Pharmacol. (1997) [Pubmed]

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