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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Inhibitor-resistant TEM (IRT) beta-lactamases with different substitutions at position 244.

A novel inhibitor-resistant TEM (IRT) beta-lactamase was detected in an Escherichia coli isolate resistant to amoxicillin-clavulanate and susceptible to cephalothin. The substrate and inhibitor profiles of this beta-lactamase were similar to those of IRT-1 and IRT-2. The novel IRT's bla gene was sequenced, and the deduced amino acid sequence showed the amino acid replacement Arg for His-244 of the TEM-1 sequence. Substitutions for Arg-244 have been reported in three TEM-1 mutants: IRT-1 (which corresponds to TEM-31) (Cys), IRT-2/TEM-30 (Ser), and TEM-41 (Thr). We designated this novel beta-lactamase, which corresponds to TEM-51, IRT-15.[1]

References

  1. Inhibitor-resistant TEM (IRT) beta-lactamases with different substitutions at position 244. Bret, L., Chaibi, E.B., Chanal-Claris, C., Sirot, D., Labia, R., Sirot, J. Antimicrob. Agents Chemother. (1997) [Pubmed]
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