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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Salmonella infection increases porcine antibacterial peptide concentrations in serum.

PR-39 is a multifunctional neutrophil peptide involved in host defense and inflammation. To investigate the involvement of PR-39 in a Salmonella choleraesuis infection, a PR-39 enzyme immunoassay was developed. The concentrations of PR-39 in serum were 13.6 +/- 1.9 ng/ml before challenge and increased (P < 0.01) threefold by 10 to 14 days postinfection. Peripheral blood neutrophil counts paralleled the changes in the concentrations of PR-39 in serum, both returned to basal values by 4 weeks postinfection. These findings suggest that the concentrations of serum PR-39 reflect the involvement of this antibacterial peptide in the host's response to an S. choleraesuis infection.[1]


  1. Salmonella infection increases porcine antibacterial peptide concentrations in serum. Zhang, G., Ross, C.R., Dritz, S.S., Nietfeld, J.C., Blecha, F. Clin. Diagn. Lab. Immunol. (1997) [Pubmed]
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