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Gene Review

PNN  -  pinin, desmosome associated protein

Sus scrofa

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Disease relevance of PNN


Psychiatry related information on PNN


High impact information on PNN

  • We have purified a PtdIns(3,4,5)P3-sensitive activator of Rac from neutrophil cytosol [6].
  • P-Rex1 antisense oligonucleotides reduced endogenous P-Rex1 expression and C5a-stimulated reactive oxygen species formation in a neutrophil-like cell line [6].
  • EL-246 blocked greater than 95% of lymphocyte adhesion to peripheral lymph node high endothelial venules and greater than 90% of neutrophil adhesion to E-selectin transfectants [7].
  • Thus, the nature and regulation of the release mechanism appear to be very similar to that of the mast cell and neutrophil [8].
  • Structure-function analyses suggest that the neutrophil chemotactic activity depends critically upon the C-1 to C-12 domain, including the stereochemistry of the 6-,8-,and 10-olefinic bonds and the presence of both hydroxyl groups [9].

Chemical compound and disease context of PNN


Biological context of PNN

  • In this reaction, the neutrophil particles serve only as a source of O2-. Further, the same changes in kinetics (decrease in apparent Km for NADPH) observed previously when granules from phagocytizing rather than resting cells were employed could be mimicked by varying the rate of O2-generation by the model system [15].
  • Although the 3' end of the open reading frame of the clone for pinin showed near identity to a partial cDNA isolated for a pig neutrophil phosphoprotein (Bellavite, P., F. Bazzoni, et al. 1990. Biochem. Biophys. Res. Commun. 170:915-922), the remaining sequence demonstrated little homology to known protein sequences [16].
  • Neutrophil implications in platelet deposition and vasoconstriction after deep arterial injury by angioplasty in pigs [17].
  • An in vivo, in situ model of neonatal cardiac surgery was established in which neutrophil adherence was manipulated by administering NPC 15669 (an inhibitor of neutrophil CD11b/CD18 surface receptor upregulation) [4].
  • Anti-idiotype as antibody against the formyl peptide chemotaxis receptor of the neutrophil [18].

Anatomical context of PNN

  • A cDNA expression library from pig blood neutrophils was immunoscreened with a rabbit antiserum raised against a 32 kDa neutrophil membrane phosphoprotein [19].
  • These findings demonstrate the presence of a Ca pump in the neutrophil plasma membrane, which is active at physiological concentrations of free cytosolic Ca [20].
  • Cl- secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue [21].
  • A reconstituted cell-free system showed that both membrane fraction and neutrophil-related cytosolic components were required for the activity. p47-phox and p67-phox were expressed in the cells [22].
  • Transmembrane linkage between surface glycoproteins and components of the cytoplasm in neutrophil leukocytes [23].

Associations of PNN with chemical compounds


Regulatory relationships of PNN


Other interactions of PNN


Analytical, diagnostic and therapeutic context of PNN


  1. Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation. Windsor, A.C., Walsh, C.J., Mullen, P.G., Cook, D.J., Fisher, B.J., Blocher, C.R., Leeper-Woodford, S.K., Sugerman, H.J., Fowler, A.A. J. Clin. Invest. (1993) [Pubmed]
  2. Role of phosphodiesterases in the regulation of endothelial permeability in vitro. Suttorp, N., Weber, U., Welsch, T., Schudt, C. J. Clin. Invest. (1993) [Pubmed]
  3. Protease-cleaved iron-transferrin augments oxidant-mediated endothelial cell injury via hydroxyl radical formation. Miller, R.A., Britigan, B.E. J. Clin. Invest. (1995) [Pubmed]
  4. Inhibition of neutrophil adherence improves postischemic ventricular performance of the neonatal heart. Wilson, I., Gillinov, A.M., Curtis, W.E., DiNatale, J., Burch, R.M., Gardner, T.J., Cameron, D.E. Circulation (1993) [Pubmed]
  5. Identification of a proline-arginine-rich antibacterial peptide from neutrophils that is analogous to PR-39, an antibacterial peptide from the small intestine. Shi, J., Ross, C.R., Chengappa, M.M., Blecha, F. J. Leukoc. Biol. (1994) [Pubmed]
  6. P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Welch, H.C., Coadwell, W.J., Ellson, C.D., Ferguson, G.J., Andrews, S.R., Erdjument-Bromage, H., Tempst, P., Hawkins, P.T., Stephens, L.R. Cell (2002) [Pubmed]
  7. Characterization of a functionally important and evolutionarily well-conserved epitope mapped to the short consensus repeats of E-selectin and L-selectin. Jutila, M.A., Watts, G., Walcheck, B., Kansas, G.S. J. Exp. Med. (1992) [Pubmed]
  8. Intracellular application of guanosine-5'-O-(3-thiotriphosphate) induces exocytotic granule fusion in guinea pig eosinophils. Nüsse, O., Lindau, M., Cromwell, O., Kay, A.B., Gomperts, B.D. J. Exp. Med. (1990) [Pubmed]
  9. Functional characterization of synthetic leukotriene B and its stereochemical isomers. Lewis, R.A., Goetzl, E.J., Drazen, J.M., Soter, N.A., Austen, K.F., Corey, E.J. J. Exp. Med. (1981) [Pubmed]
  10. E-selectin ligands mediate tumor necrosis factor-induced neutrophil sequestration and pulmonary edema in guinea pig lungs. Lo, S.K., Bevilacqua, B., Malik, A.B. Circ. Res. (1994) [Pubmed]
  11. C5a-induced neutrophilia. A primary humoral mechanism for recruitment of neutrophils. Kajita, T., Hugli, T.E. Am. J. Pathol. (1990) [Pubmed]
  12. Selective inhibition of human neutrophil chemotaxis to N-formyl-methionyl-leucyl-phenylalanine by sulfones. Harvath, L., Yancey, K.B., Katz, S.I. J. Immunol. (1986) [Pubmed]
  13. Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. A possible role of the toxin substrate in Ca2+-mobilizing receptor-mediated signal transduction. Okajima, F., Katada, T., Ui, M. J. Biol. Chem. (1985) [Pubmed]
  14. Modulation of the inflammatory response in experimental myocardial infarction. Bohle, R.M., Pich, S., Klein, H.H. Eur. Heart J. (1991) [Pubmed]
  15. Manganese-dependent NADPH oxidation by granulocyte particles. The role of superoxide and the nonphysiological nature of the manganese requirement. Curnutte, J.T., Karnovsky, M.L., Babior, B.M. J. Clin. Invest. (1976) [Pubmed]
  16. Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex. Ouyang, P., Sugrue, S.P. J. Cell Biol. (1996) [Pubmed]
  17. Neutrophil implications in platelet deposition and vasoconstriction after deep arterial injury by angioplasty in pigs. Merhi, Y., Lacoste, L.L., Lam, J.Y. Circulation (1994) [Pubmed]
  18. Anti-idiotype as antibody against the formyl peptide chemotaxis receptor of the neutrophil. Marasco, W.A., Becker, E.L. J. Immunol. (1982) [Pubmed]
  19. Isolation and characterization of a cDNA clone for a novel serine-rich neutrophil protein. Bellavite, P., Bazzoni, F., Cassatella, M.A., Hunter, K.J., Bannister, J.V. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  20. Adenosine triphosphate-dependent calcium pump in the plasma membrane of guinea pig and human neutrophils. Lagast, H., Lew, P.D., Waldvogel, F.A. J. Clin. Invest. (1984) [Pubmed]
  21. Cl- secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue. Madara, J.L., Parkos, C., Colgan, S., MacLeod, R.J., Nash, S., Matthews, J., Delp, C., Lencer, W. J. Clin. Invest. (1992) [Pubmed]
  22. Guinea pig gastric mucosal cells produce abundant superoxide anion through an NADPH oxidase-like system. Teshima, S., Rokutan, K., Nikawa, T., Kishi, K. Gastroenterology (1998) [Pubmed]
  23. Transmembrane linkage between surface glycoproteins and components of the cytoplasm in neutrophil leukocytes. Sheterline, P., Hopkins, C.R. J. Cell Biol. (1981) [Pubmed]
  24. Effects of neutrophil elastase and other proteases on porcine aortic endothelial prostaglandin I2 production, adenine nucleotide release, and responses to vasoactive agents. LeRoy, E.C., Ager, A., Gordon, J.L. J. Clin. Invest. (1984) [Pubmed]
  25. Insight into the nature and site of oxygen-centered free radical generation by endothelial cell monolayers using a novel spin trapping technique. Britigan, B.E., Roeder, T.L., Shasby, D.M. Blood (1992) [Pubmed]
  26. Granulocyte colony-stimulating factor does not enhance endotoxin-induced acute lung injury in guinea pigs. Kanazawa, M., Ishizaka, A., Hasegawa, N., Suzuki, Y., Yokoyama, T. Am. Rev. Respir. Dis. (1992) [Pubmed]
  27. Activated neutrophils induce hyperpermeability and phosphorylation of adherens junction proteins in coronary venular endothelial cells. Tinsley, J.H., Wu, M.H., Ma, W., Taulman, A.C., Yuan, S.Y. J. Biol. Chem. (1999) [Pubmed]
  28. Transferrin induces maturation of neutrophil granulocyte precursors in vitro. Evans, W.H., Wilson, S.M., Mage, M.G. Leuk. Res. (1986) [Pubmed]
  29. Molecular cloning of porcine alveolar macrophage-derived neutrophil chemotactic factors I and II; identification of porcine IL-8 and another intercrine-alpha protein. Goodman, R.B., Foster, D.C., Mathewes, S.L., Osborn, S.G., Kuijper, J.L., Forstrom, J.W., Martin, T.R. Biochemistry (1992) [Pubmed]
  30. Guinea Pig Neutrophils Infected with Mycobacterium tuberculosis Produce Cytokines Which Activate Alveolar Macrophages in Noncontact Cultures. Sawant, K.V., McMurray, D.N. Infect. Immun. (2007) [Pubmed]
  31. Porcine spermadhesin PSP-I/PSP-II stimulates macrophages to release a neutrophil chemotactic substance: modulation by mast cells. Assreuy, A.M., Alencar, N.M., Cavada, B.S., Rocha-Filho, D.R., Feitosa, R.F., Cunha, F.Q., Calvete, J.J., Ribeiro, R.A. Biol. Reprod. (2003) [Pubmed]
  32. Goblet cell degranulation after antigen challenge in sensitized guinea pigs. Role of neutrophils. Agusti, C., Takeyama, K., Cardell, L.O., Ueki, I., Lausier, J., Lou, Y.P., Nadel, J.A. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  33. Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds. Cole, A.M., Shi, J., Ceccarelli, A., Kim, Y.H., Park, A., Ganz, T. Blood (2001) [Pubmed]
  34. Isolation and characterization of the neutrophil-binding proteins for platelet-derived adherence-inhibiting factor. Iwabuchi, K., Nagaoka, I., Someya, A., Yamashita, T. Blood (1993) [Pubmed]
  35. Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. Ames, R.S., Lee, D., Foley, J.J., Jurewicz, A.J., Tornetta, M.A., Bautsch, W., Settmacher, B., Klos, A., Erhard, K.F., Cousins, R.D., Sulpizio, A.C., Hieble, J.P., McCafferty, G., Ward, K.W., Adams, J.L., Bondinell, W.E., Underwood, D.C., Osborn, R.R., Badger, A.M., Sarau, H.M. J. Immunol. (2001) [Pubmed]
  36. A 63-kilodalton cytosolic polypeptide involved in superoxide generation in porcine neutrophils. Purification and characterization. Tanaka, T., Imajoh-Ohmi, S., Kanegasaki, S., Takagi, Y., Makino, R., Ishimura, Y. J. Biol. Chem. (1990) [Pubmed]
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