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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The rat gene homologous to the human gene 9-27 is involved in the development of the mammary gland.

We have developed a model system for studying differentiation in the mammary gland, by using two clonal cultures deriving from a rat breast adenocarcinoma. They differ in the ability to form domes, structures the significance of which is unknown. By using the subtractive cDNA library approach, we isolated a cDNA that is highly expressed in the dome-forming cells, and identical to the rat8 gene and highly homologous to the human 9-27 gene. Antisense treatment of the dome-forming cells specifically and reproducibly abolishes dome formation, while forced expression of the gene in non-dome-forming cells causes morphological changes suggestive of "flat" domes. In situ hybridization on rat tissues shows that the gene is expressed in epithelia, especially in those forming tubular structures, suggesting a relatedness between these structures and domes. Cytokeratin 8 and E cadherin are strongly expressed in the domes but not outside them, suggesting that the rat8 gene triggers the cells to express molecules that tighten the lateral connections between the cells; the process is likely to parallel that occurring during the differentiation of the mammary gland.[1]

References

  1. The rat gene homologous to the human gene 9-27 is involved in the development of the mammary gland. Zucchi, I., Montagna, C., Susani, L., Vezzoni, P., Dulbecco, R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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