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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism.

Several mitogen-activated protein kinase kinase kinases (MAPKKKs), including NF-kappa B-inducing kinase ( NIK), play critical roles in NF-kappa B activation. We isolated cDNA for human TGF-beta activated kinase 1 ( TAK1), a member of the MAPKKK family, and evaluated its ability to stimulate NF-kappa B activation. Overexpression of TAK1 together with its activator protein, TAK1 binding protein 1 (TAB1), induced the nuclear translocation of NF-kappa B p50/ p65 heterodimer accompanied by the degradation of I kappa B alpha and I kappa B beta, and the expression of kappa B-dependent reporter gene. A dominant negative mutant of NIK did not inhibit TAK1- induced NF-kappa B activation. These results suggest that TAK1 induces NF-kappa B activation through a novel NIK-independent signaling pathway.[1]

References

  1. TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism. Sakurai, H., Shigemori, N., Hasegawa, K., Sugita, T. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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