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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Destruxin-A4 chlorohydrin, a novel destruxin from fungus OS-F68576: isolation, structure determination, and biological activity as an inducer of erythropoietin.
In the course of screening for small-molecule modulators of erythropoietingene expression, five destruxins were isolated from the fungal culture of OS-F68576. The structures were elucidated by extensive 1H and 13C NMR spectroscopy and by hydrolytic modification. One compound (destruxin-A4 chlorohydrin, 1) is a novel destruxin. All these compounds induced erythropoietingene expression 5-fold at concentration of 0.2-2 microM.[1]
