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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Activin and bone morphogenetic protein ( BMP) signalling during tooth development.

Activins and bone morphogenetic proteins (BMPs) belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related cytokines. Results of recent in vivo and in vitro studies suggest that activin A, several BMPs, and their cell surface receptors may participate in tooth development. In addition, follistatin an extracellular protein that may interact with activin and BMP signaling, appears to be involved. This review focuses on recent advances in relation to the roles of activin/ BMP receptors, their ligands and extracellular modifiers during tooth development.[1]


  1. Activin and bone morphogenetic protein (BMP) signalling during tooth development. Heikinheimo, K., Bègue-Kirn, C., Ritvos, O., Tuuri, T., Ruch, J.V. Eur. J. Oral Sci. (1998) [Pubmed]
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