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Gene Review

Bmp1  -  bone morphogenetic protein 1

Mus musculus

Synonyms: BMP-1, Bone morphogenetic protein 1, Mammalian tolloid protein, PCP, Pcp, ...
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Disease relevance of Bmp1

  • The role of TGF-beta/bone morphogenetic protein signaling in the chondrogenic differentiation of human synovial fibroblasts (SFs) was examined with the adenovirus vector-mediated gene transduction system [1].
  • The ability to enhance BMP signaling while suppressing TGF-beta activation indicates a critical role for KCP in modulating the responses between these anti- and profibrotic cytokines in the initiation and progression of renal interstitial fibrosis [2].
  • The bone morphogenetic protein (BMP)2 gene has been genetically linked to osteoporosis and osteoarthritis [3].
  • The spinal neural tube defect results from a different mechanism: increased BMP signaling in the mesoderm between the limb buds leads to abnormal somite differentiation and axial skeletal malformation [4].
  • Modulator of bone morphogenetic protein activity in the progression of kidney diseases [5].

Psychiatry related information on Bmp1

  • Mice without water deprivation were given PCP or saline before a training trial, which consisted of exposure to a novel open-field environment with an alcove containing a water tube [6].
  • Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay [7].
  • 5. Pretreatment with PCP (3-30 mg kg-1) or MK-801 (0.1-1.6 mg kg-1) significantly increased locomotor activity in mice [8].
  • There was a significant inverse relationship between the step-down and escape latencies, indicating that PCP had induced amnesia [9].
  • OBJECTIVE: To investigate how the background genotype contributes to glutamate's effects on attention and response control, we examined how phencyclidine (PCP) affected the performance of a five-choice serial reaction time (5-CSRT) task in two inbred mouse strains, C57BL/6N and DBA/2N [10].

High impact information on Bmp1


Chemical compound and disease context of Bmp1

  • Whereas it was thought that estrogens work exclusively by inhibiting bone resorption, our previous results show that 17beta-estradiol (E2) increases mouse bone morphogenetic protein (BMP)-2 mRNA, suggesting that estrogens may also enhance bone formation [16].
  • Furthermore, phencyclidine (PCP) (2 mg/kg) can selectively induce social withdrawal in naive rats that were housed in pairs (familiar) for 10 days prior to testing without affecting motor activity [17].
  • In the present experiment, locomotor activity and performance on an inverted screen test in untrained mice were used to differentiate PCP-type non-competitive NMDA antagonists from other drug classes [18].
  • This baseline was explored using three manipulations employed in the clinical management of PCP toxicity: treatment with a neuroleptic (haloperidol), a benzodiazepine (chlordiazepoxide) and modification in environmental stimulation (changing of lighting conditions) [19].
  • These uncompetitive NMDA antagonists [PCP, dizocilpine, (-)-MK-801, TCP, (+)-SKF 10,047, dextrorphan, ketamine] produced dose-related increases in locomotor activity and the percentage of mice falling off an inverted, elevated wire mesh screen [18].

Biological context of Bmp1


Anatomical context of Bmp1


Associations of Bmp1 with chemical compounds

  • Here, we show that BMP-1 cleaves probiglycan at a single site, removing the propeptide and producing a biglycan molecule with an NH(2) terminus identical to that of the mature form found in tissues [28].
  • We report here that significant osteogenesis, as determined by gene expression and histological analysis, is induced only when mouse ADAS are cultured in the presence of retinoic acid with or without recombinant human bone morphogenetic protein (BMP)-2 supplementation [29].
  • Studies have shown that the minimal structure for procollagen proteinase activity is proteinase-CUB1-CUB2 (BMP-1DeltaEC3) and therefore lacking the epidermal growth factor (EGF)-like domain thought to account for the Ca(2+) dependence of BMP-1 [30].
  • Collectively, these findings provide novel insights into BMP action and demonstrate that BMP signaling governs the fate of prechondrogenic mesenchyme, at least in part, through regulation of retinoid signaling [31].
  • Type I procollagen COOH-terminal proteinase (C-proteinase) enhancer, a glycoprotein that binds to the COOH-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity, was purified from mouse fibroblast culture media [32].

Physical interactions of Bmp1

  • Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression [33].

Regulatory relationships of Bmp1

  • BMP-induced Smad1 and Smad5 activation of GCCG-mediated transcription was blocked in the presence of CIZ overexpression [21].
  • Here we show that the 36 kDa, active fragment of PCPE enhances the activity of both the short (mouse) and long (chick) forms of PCP/BMP-1 [34].
  • The mammalian bone morphogenetic protein-1 (BMP-1)/Tolloid-related metalloproteinases play key roles in regulating formation of the extracellular matrix (ECM) via biosynthetic processing of various precursor proteins into mature functional enzymes, structural proteins, and proteins involved in initiating the mineralization of hard tissue ECMs [35].
  • These data show that BMP9 activates the canonical BMP signaling pathway and suggest that this could be one of the mechanisms responsible for the induction of the cholinergic phenotype by BMP9 in the basal forebrain [36].
  • Pax3 regulates morphogenetic cell behavior in vitro coincident with activation of a PCP/non-canonical Wnt-signaling cascade [37].

Other interactions of Bmp1

  • The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart [38].
  • These data indicate that CIZ is a novel type inhibitor of BMP/Smad signaling [21].
  • Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis [35].
  • Finally, when the amount of PCP is adjusted so that the rate of C-terminal processing remains constant, PCPE (36 kDa) has no effect on the assembly of collagen or pN-collagen in vitro following C-terminal processing of the corresponding precursors [34].
  • These results provide limited support for the anti-BMP model of inhibin action and reveal that, relative to inhibin A, inhibin B essentially behaves as a selective activin antagonist in AC cells [27].

Analytical, diagnostic and therapeutic context of Bmp1


  1. Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts. Seto, H., Kamekura, S., Miura, T., Yamamoto, A., Chikuda, H., Ogata, T., Hiraoka, H., Oda, H., Nakamura, K., Kurosawa, H., Chug, U.I., Kawaguchi, H., Tanaka, S. J. Clin. Invest. (2004) [Pubmed]
  2. The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia. Lin, J., Patel, S.R., Wang, M., Dressler, G.R. Mol. Cell. Biol. (2006) [Pubmed]
  3. A polymorphism in a conserved posttranscriptional regulatory motif alters bone morphogenetic protein 2 (BMP2) RNA:protein interactions. Fritz, D.T., Jiang, S., Xu, J., Rogers, M.B. Mol. Endocrinol. (2006) [Pubmed]
  4. The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms. Stottmann, R.W., Berrong, M., Matta, K., Choi, M., Klingensmith, J. Dev. Biol. (2006) [Pubmed]
  5. Modulator of bone morphogenetic protein activity in the progression of kidney diseases. Yanagita, M. Kidney Int. (2006) [Pubmed]
  6. Phencyclidine impairs latent learning in mice: interaction between glutamatergic systems and sigma(1) receptors. Noda, A., Noda, Y., Kamei, H., Ichihara, K., Mamiya, T., Nagai, T., Sugiura, S., Furukawa, H., Nabeshima, T. Neuropsychopharmacology (2001) [Pubmed]
  7. Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogues. Thurkauf, A., de Costa, B., Yamaguchi, S., Mattson, M.V., Jacobson, A.E., Rice, K.C., Rogawski, M.A. J. Med. Chem. (1990) [Pubmed]
  8. The glycine/NMDA receptor antagonist, R-(+)-HA-966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents. Bristow, L.J., Hutson, P.H., Thorn, L., Tricklebank, M.D. Br. J. Pharmacol. (1993) [Pubmed]
  9. Phencyclidine-induced retrograde amnesia in mice. Nabeshima, T., Kozawa, T., Furukawa, H., Kameyama, T. Psychopharmacology (Berl.) (1986) [Pubmed]
  10. Phencyclidine-induced impairment in attention and response control depends on the background genotype of mice: reversal by the mGLU(2/3) receptor agonist LY379268. Greco, B., Invernizzi, R.W., Carli, M. Psychopharmacology (Berl.) (2005) [Pubmed]
  11. Requirement of Bmpr1a for Müllerian duct regression during male sexual development. Jamin, S.P., Arango, N.A., Mishina, Y., Hanks, M.C., Behringer, R.R. Nat. Genet. (2002) [Pubmed]
  12. Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Yoshida, Y., Tanaka, S., Umemori, H., Minowa, O., Usui, M., Ikematsu, N., Hosoda, E., Imamura, T., Kuno, J., Yamashita, T., Miyazono, K., Noda, M., Noda, T., Yamamoto, T. Cell (2000) [Pubmed]
  13. The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Kingsley, D.M., Bland, A.E., Grubber, J.M., Marker, P.C., Russell, L.B., Copeland, N.G., Jenkins, N.A. Cell (1992) [Pubmed]
  14. The organizer factors Chordin and Noggin are required for mouse forebrain development. Bachiller, D., Klingensmith, J., Kemp, C., Belo, J.A., Anderson, R.M., May, S.R., McMahon, J.A., McMahon, A.P., Harland, R.M., Rossant, J., De Robertis, E.M. Nature (2000) [Pubmed]
  15. The bone morphogenetic protein system in mammalian reproduction. Shimasaki, S., Moore, R.K., Otsuka, F., Erickson, G.F. Endocr. Rev. (2004) [Pubmed]
  16. Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells. Zhou, S., Turgeman, G., Harris, S.E., Leitman, D.C., Komm, B.S., Bodine, P.V., Gazit, D. Mol. Endocrinol. (2003) [Pubmed]
  17. Antipsychotic agents antagonize non-competitive N-methyl-D-aspartate antagonist-induced behaviors. Corbett, R., Camacho, F., Woods, A.T., Kerman, L.L., Fishkin, R.J., Brooks, K., Dunn, R.W. Psychopharmacology (Berl.) (1995) [Pubmed]
  18. Sensitive and rapid behavioral differentiation of N-methyl-D-aspartate receptor antagonists. Ginski, M.J., Witkin, J.M. Psychopharmacology (Berl.) (1994) [Pubmed]
  19. A time-activity baseline to measure pharmacological and non-pharmacological manipulations of PCP-induced activity in mice. McAllister, K.H. Psychopharmacology (Berl.) (1997) [Pubmed]
  20. Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. Suzuki, N., Labosky, P.A., Furuta, Y., Hargett, L., Dunn, R., Fogo, A.B., Takahara, K., Peters, D.M., Greenspan, D.S., Hogan, B.L. Development (1996) [Pubmed]
  21. Negative regulation of bone morphogenetic protein/Smad signaling by Cas-interacting zinc finger protein in osteoblasts. Shen, Z.J., Nakamoto, T., Tsuji, K., Nifuji, A., Miyazono, K., Komori, T., Hirai, H., Noda, M. J. Biol. Chem. (2002) [Pubmed]
  22. bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis. Jasuja, R., Voss, N., Ge, G., Hoffman, G.G., Lyman-Gingerich, J., Pelegri, F., Greenspan, D.S. Mech. Dev. (2006) [Pubmed]
  23. Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1. Takahara, K., Brevard, R., Hoffman, G.G., Suzuki, N., Greenspan, D.S. Genomics (1996) [Pubmed]
  24. Twisted Gastrulation Modulates Bone Morphogenetic Protein-induced Collagen II and X Expression in Chondrocytes in Vitro and in Vivo. Schmidl, M., Adam, N., Surmann-Schmitt, C., Hattori, T., Stock, M., Dietz, U., de Crombrugghe, B., P??schl, E., von der Mark, K. J. Biol. Chem. (2006) [Pubmed]
  25. Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures. Uzel, M.I., Scott, I.C., Babakhanlou-Chase, H., Palamakumbura, A.H., Pappano, W.N., Hong, H.H., Greenspan, D.S., Trackman, P.C. J. Biol. Chem. (2001) [Pubmed]
  26. BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning. Ovchinnikov, D.A., Selever, J., Wang, Y., Chen, Y.T., Mishina, Y., Martin, J.F., Behringer, R.R. Dev. Biol. (2006) [Pubmed]
  27. Inhibins differentially antagonize activin and bone morphogenetic protein action in a mouse adrenocortical cell line. Farnworth, P.G., Stanton, P.G., Wang, Y., Escalona, R., Findlay, J.K., Ooi, G.T. Endocrinology (2006) [Pubmed]
  28. Bone morphogenetic protein-1 processes probiglycan. Scott, I.C., Imamura, Y., Pappano, W.N., Troedel, J.M., Recklies, A.D., Roughley, P.J., Greenspan, D.S. J. Biol. Chem. (2000) [Pubmed]
  29. Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling. Wan, D.C., Shi, Y.Y., Nacamuli, R.P., Quarto, N., Lyons, K.M., Longaker, M.T. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  30. Deletion of epidermal growth factor-like domains converts mammalian tolloid into a chordinase and effective procollagen C-proteinase. Garrigue-Antar, L., François, V., Kadler, K.E. J. Biol. Chem. (2004) [Pubmed]
  31. BMP action in skeletogenesis involves attenuation of retinoid signaling. Hoffman, L.M., Garcha, K., Karamboulas, K., Cowan, M.F., Drysdale, L.M., Horton, W.A., Underhill, T.M. J. Cell Biol. (2006) [Pubmed]
  32. Type I procollagen COOH-terminal proteinase enhancer protein: identification, primary structure, and chromosomal localization of the cognate human gene (PCOLCE). Takahara, K., Kessler, E., Biniaminov, L., Brusel, M., Eddy, R.L., Jani-Sait, S., Shows, T.B., Greenspan, D.S. J. Biol. Chem. (1994) [Pubmed]
  33. Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression. Frontelo, P., Leader, J.E., Yoo, N., Potocki, A.C., Crawford, M., Kulik, M., Lechleider, R.J. Oncogene (2004) [Pubmed]
  34. The CUB domains of procollagen C-proteinase enhancer control collagen assembly solely by their effect on procollagen C-proteinase/bone morphogenetic protein-1. Hulmes, D.J., Mould, A.P., Kessler, E. Matrix Biol. (1997) [Pubmed]
  35. Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis. Ge, G., Seo, N.S., Liang, X., Hopkins, D.R., Höök, M., Greenspan, D.S. J. Biol. Chem. (2004) [Pubmed]
  36. Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain. Lopez-Coviella, I., Mellott, T.M., Kovacheva, V.P., Berse, B., Slack, B.E., Zemelko, V., Schnitzler, A., Blusztajn, J.K. Brain Res. (2006) [Pubmed]
  37. Pax3 regulates morphogenetic cell behavior in vitro coincident with activation of a PCP/non-canonical Wnt-signaling cascade. Wiggan, O., Hamel, P.A. J. Cell. Sci. (2002) [Pubmed]
  38. The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart. Clark, T.G., Conway, S.J., Scott, I.C., Labosky, P.A., Winnier, G., Bundy, J., Hogan, B.L., Greenspan, D.S. Development (1999) [Pubmed]
  39. Detection of multiple bone morphogenetic protein messenger ribonucleic acids and their signal transducer, Smad1, during mouse decidualization. Ying, Y., Zhao, G.Q. Biol. Reprod. (2000) [Pubmed]
  40. BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cells. Buckley, S., Shi, W., Driscoll, B., Ferrario, A., Anderson, K., Warburton, D. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  41. Enamel matrix derivative stimulates core binding factor alpha1/Runt-related transcription factor-2 expression via activation of Smad1 in C2C12 cells. Takayama, T., Suzuki, N., Narukawa, M., Tokunaga, T., Otsuka, K., Ito, K. J. Periodontol. (2005) [Pubmed]
  42. Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. Hardwick, J.C., Van Den Brink, G.R., Bleuming, S.A., Ballester, I., Van Den Brande, J.M., Keller, J.J., Offerhaus, G.J., Van Deventer, S.J., Peppelenbosch, M.P. Gastroenterology (2004) [Pubmed]
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