Gene Review:
Tgfb1 - transforming growth factor, beta 1
Mus musculus
Synonyms:
TGF-beta 1, TGF-beta-1, TGF-beta1, TGFbeta1, Tgfb, ...
Yin,
Narula,
Singh,
Murphy,
Jared A. Weis,
ten Dijke,
Chen,
Heldin,
Bhattacherjee,
Delvoux,
Itoh,
Ormsby,
Gressner,
Roncarolo,
Ronald L. Chandler,
Wyss-Coray,
Itoh,
Bonzel,
Warner,
ten Dijke,
Pisano,
Franzén,
Streckert,
Stopa,
Anna Chytil,
Ho,
Doetschman,
Heldin,
Greene,
Zeller,
Agnieszka E. Gorska,
Douglas P. Mortlock,
Masliah,
Miyazono,
Valdimarsdottir,
Persson,
Anna Spagnoli,
Berezovskaya,
Goumans,
Boussiotis,
Souchelnytskyi,
Lara Longobardi,
Mukhopadhyay,
Lynda O'Rear,
Dooley,
Kallapur,
Harold L. Moses,
Froilan Granero-Molto,
Blazar,
Kimberly Shimer,
ten Dijke,
- TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes. Bommireddy, R., Ormsby, I., Yin, M., Boivin, G.P., Babcock, G.F., Doetschman, T. J. Immunol. (2003)
- TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cells: transcriptional activation of I kappa B alpha. Arsura, M., Wu, M., Sonenshein, G.E. Immunity (1996)
- The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia. Lin, J., Patel, S.R., Wang, M., Dressler, G.R. Mol. Cell. Biol. (2006)
- Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice. Chagraoui, H., Komura, E., Tulliez, M., Giraudier, S., Vainchenker, W., Wendling, F. Blood (2002)
- Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells. Lotem, J., Sachs, L. Blood (1992)
- Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis. Cheng, N., Chytil, A., Shyr, Y., Joly, A., Moses, H.L. Cancer Res. (2007)
- Erythropoietin decreases renal fibrosis in mice with ureteral obstruction: role of inhibiting TGF-beta-induced epithelial-to-mesenchymal transition. Park, S.H., Choi, M.J., Song, I.K., Choi, S.Y., Nam, J.O., Kim, C.D., Lee, B.H., Park, R.W., Park, K.M., Kim, Y.J., Kim, I.S., Kwon, T.H., Kim, Y.L. J. Am. Soc. Nephrol. (2007)
- Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage. Saxena, V., Lienesch, D.W., Zhou, M., Bommireddy, R., Azhar, M., Doetschman, T., Singh, R.R. J. Immunol. (2008)
- TGFbeta inhibition of yolk-sac-like differentiation of human embryonic stem-cell-derived embryoid bodies illustrates differences between early mouse and human development. Poon, E., Clermont, F., Firpo, M.T., Akhurst, R.J. J. Cell. Sci. (2006)
- Functional role of TGF beta in Alzheimer's disease microvascular injury: lessons from transgenic mice. Masliah, E., Ho, G., Wyss-Coray, T. Neurochem. Int. (2001)
- Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse. Yaswen, L., Kulkarni, A.B., Fredrickson, T., Mittleman, B., Schiffman, R., Payne, S., Longenecker, G., Mozes, E., Karlsson, S. Blood (1996)
- Microglial activation varies in different models of Creutzfeldt-Jakob disease. Baker, C.A., Lu, Z.Y., Zaitsev, I., Manuelidis, L. J. Virol. (1999)
- Alcohol and hepatitis C virus core protein additively increase lipid peroxidation and synergistically trigger hepatic cytokine expression in a transgenic mouse model. Perlemuter, G., Lettéron, P., Carnot, F., Zavala, F., Pessayre, D., Nalpas, B., Bréchot, C. J. Hepatol. (2003)
- The Orphan Nuclear Receptor RORgammat Directs the Differentiation Program of Proinflammatory IL-17(+) T Helper Cells. Ivanov, I.I., McKenzie, B.S., Zhou, L., Tadokoro, C.E., Lepelley, A., Lafaille, J.J., Cua, D.J., Littman, D.R. Cell (2006)
- Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling. Datto, M., Wang, X.F. Cell (2005)
- Causal relationship between the loss of RUNX3 expression and gastric cancer. Li, Q.L., Ito, K., Sakakura, C., Fukamachi, H., Inoue, K., Chi, X.Z., Lee, K.Y., Nomura, S., Lee, C.W., Han, S.B., Kim, H.M., Kim, W.J., Yamamoto, H., Yamashita, N., Yano, T., Ikeda, T., Itohara, S., Inazawa, J., Abe, T., Hagiwara, A., Yamagishi, H., Ooe, A., Kaneda, A., Sugimura, T., Ushijima, T., Bae, S.C., Ito, Y. Cell (2002)
- Regulation of left-right patterning in mice by growth/differentiation factor-1. Rankin, C.T., Bunton, T., Lawler, A.M., Lee, S.J. Nat. Genet. (2000)
- Cultured tubule cells from TGF-beta1 null mice exhibit impaired hypertrophy and fibronectin expression in high glucose. Chen, S., Hoffman, B.B., Lee, J.S., Kasama, Y., Jim, B., Kopp, J.B., Ziyadeh, F.N. Kidney Int. (2004)
- Role of TGF-beta in RA-induced cleft palate in CD-1 mice. Degitz, S.J., Morris, D., Foley, G.L., Francis, B.M. Teratology (1998)
- Effects of dietary omega3 and omega6 lipids and vitamin E on proliferative response, lymphoid cell subsets, production of cytokines by spleen cells, and splenic protein levels for cytokines and oncogenes in MRL/MpJ-lpr/lpr mice. Venkatraman, J.T., Chu, W.C. J. Nutr. Biochem. (1999)
- Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells. Galliher, A.J., Schiemann, W.P. Breast Cancer Res. (2006)
- Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors. Muraoka-Cook, R.S., Kurokawa, H., Koh, Y., Forbes, J.T., Roebuck, L.R., Barcellos-Hoff, M.H., Moody, S.E., Chodosh, L.A., Arteaga, C.L. Cancer Res. (2004)
- Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice. Bonyadi, M., Rusholme, S.A., Cousins, F.M., Su, H.C., Biron, C.A., Farrall, M., Akhurst, R.J. Nat. Genet. (1997)
- Delayed wound healing in immunodeficient TGF-beta 1 knockout mice. Crowe, M.J., Doetschman, T., Greenhalgh, D.G. J. Invest. Dermatol. (2000)
- Strain dependency of TGFbeta1 function during embryogenesis. Kallapur, S., Ormsby, I., Doetschman, T. Mol. Reprod. Dev. (1999)
- Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. Reynolds, L.E., Conti, F.J., Lucas, M., Grose, R., Robinson, S., Stone, M., Saunders, G., Dickson, C., Hynes, R.O., Lacy-Hulbert, A., Hodivala-Dilke, K. Nat. Med. (2005)
- TGF-beta 1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes. Bommireddy, R., Saxena, V., Ormsby, I., Yin, M., Boivin, G.P., Babcock, G.F., Singh, R.R., Doetschman, T. J. Immunol. (2003)
- Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice. Cui, W., Fowlis, D.J., Cousins, F.M., Duffie, E., Bryson, S., Balmain, A., Akhurst, R.J. Genes Dev. (1995)
- TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Liu, D., Black, B.L., Derynck, R. Genes Dev. (2001)
- Transforming growth factor (TGF-beta)-specific signaling by chimeric TGF-beta type II receptor with intracellular domain of activin type IIB receptor. Persson, U., Souchelnytskyi, S., Franzén, P., Miyazono, K., ten Dijke, P., Heldin, C.H. J. Biol. Chem. (1997)
- Inhibition of p38 Mitogen-Activated Protein Kinase and Transforming Growth Factor-{beta}1/Smad Signaling Pathways Modulates the Development of Fibrosis in Adriamycin-Induced Nephropathy. Li, J., Campanale, N.V., Liang, R.J., Deane, J.A., Bertram, J.F., Ricardo, S.D. Am. J. Pathol. (2006)
- TGF-beta signaling is required for the function of insulin-reactive T regulatory cells. Du, W., Wong, F.S., Li, M.O., Peng, J., Qi, H., Flavell, R.A., Sherwin, R., Wen, L. J. Clin. Invest. (2006)
- Lead induces chondrogenesis and alters transforming growth factor-beta and bone morphogenetic protein signaling in mesenchymal cell populations. Zuscik, M.J., Ma, L., Buckley, T., Puzas, J.E., Drissi, H., Schwarz, E.M., O'Keefe, R.J. Environ. Health Perspect. (2007)
- Betaglycan expression is transcriptionally up-regulated during skeletal muscle differentiation. Cloning of murine betaglycan gene promoter and its modulation by MyoD, retinoic acid, and transforming growth factor-beta. Lopez-Casillas, F., Riquelme, C., Perez-Kato, Y., Ponce-Castaneda, M.V., Osses, N., Esparza-Lopez, J., Gonzalez-Nunez, G., Cabello-Verrugio, C., Mendoza, V., Troncoso, V., Brandan, E. J. Biol. Chem. (2003)
- TGF-beta modulates the expression of retinoic acid-induced RAR-beta in primary cultures of embryonic palate cells. Nugent, P., Potchinsky, M., Lafferty, C., Greene, R.M. Exp. Cell Res. (1995)
- Mechanisms underlying TGF-{beta}1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis. Jeon, S.H., Chae, B.C., Kim, H.A., Seo, G.Y., Seo, D.W., Chun, G.T., Kim, N.S., Yie, S.W., Byeon, W.H., Eom, S.H., Ha, K.S., Kim, Y.M., Kim, P.H. J. Leukoc. Biol. (2007)
- Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. Fontana, L., Chen, Y., Prijatelj, P., Sakai, T., Fässler, R., Sakai, L.Y., Rifkin, D.B. FASEB J. (2005)
- Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells. Valdimarsdottir, G., Goumans, M.J., Itoh, F., Itoh, S., Heldin, C.H., ten Dijke, P. BMC Cell Biol. (2006)
- Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepatic stellate cells. Dooley, S., Delvoux, B., Streckert, M., Bonzel, L., Stopa, M., ten Dijke, P., Gressner, A.M. FEBS Lett. (2001)
- Functional interaction between Smad, CREB binding protein, and p68 RNA helicase. Warner, D.R., Bhattacherjee, V., Yin, X., Singh, S., Mukhopadhyay, P., Pisano, M.M., Greene, R.M. Biochem. Biophys. Res. Commun. (2004)
- Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. Li, T.F., Chen, D., Wu, Q., Chen, M., Sheu, T.J., Schwarz, E.M., Drissi, H., Zuscik, M., O'Keefe, R.J. J. Biol. Chem. (2006)
- JNK regulates autocrine expression of TGF-beta1. Ventura, J.J., Kennedy, N.J., Flavell, R.A., Davis, R.J. Mol. Cell (2004)
- Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice. Leu, J.I., Crissey, M.A., Taub, R. J. Clin. Invest. (2003)
- Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. Lamouille, S., Derynck, R. J. Cell Biol. (2007)
- Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis. Ramjaun, A.R., Tomlinson, S., Eddaoudi, A., Downward, J. Oncogene (2007)
- FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype. Liu, S., Xu, S.W., Kennedy, L., Pala, D., Chen, Y., Eastwood, M., Carter, D.E., Black, C.M., Abraham, D.J., Leask, A. Mol. Biol. Cell (2007)
- Phosphorylation of the cyclic AMP response element binding protein mediates transforming growth factor beta-induced downregulation of cyclin A in vascular smooth muscle cells. Kamiya, K., Sakakibara, K., Ryer, E.J., Hom, R.P., Leof, E.B., Kent, K.C., Liu, B. Mol. Cell. Biol. (2007)
- TGF-beta signaling is essential for joint morphogenesis. Spagnoli, A., O'Rear, L., Chandler, R.L., Granero-Molto, F., Mortlock, D.P., Gorska, A.E., Weis, J.A., Longobardi, L., Chytil, A., Shimer, K., Moses, H.L. J. Cell Biol. (2007)
- Astrocyte-derived TGF-beta 2 and NGF differentially regulate neural recognition molecule expression by cultured astrocytes. Saad, B., Constam, D.B., Ortmann, R., Moos, M., Fontana, A., Schachner, M. J. Cell Biol. (1991)
- Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2. Lin, D.W., Chang, I.C., Tseng, A., Wu, M.L., Chen, C.H., Patenaude, C.A., Layne, M.D., Yet, S.F. J. Biol. Chem. (2008)
- Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. Kokudo, T., Suzuki, Y., Yoshimatsu, Y., Yamazaki, T., Watabe, T., Miyazono, K. J. Cell. Sci. (2008)
- Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1. Alcorn, J.F., Guala, A.S., van der Velden, J., McElhinney, B., Irvin, C.G., Davis, R.J., Janssen-Heininger, Y.M. J. Cell. Sci. (2008)
- Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice. Larsson, J., Goumans, M.J., Sjöstrand, L.J., van Rooijen, M.A., Ward, D., Levéen, P., Xu, X., ten Dijke, P., Mummery, C.L., Karlsson, S. EMBO J. (2001)
- Altered T-cell receptor + CD28-mediated signaling and blocked cell cycle progression in interleukin 10 and transforming growth factor-beta-treated alloreactive T cells that do not induce graft-versus-host disease. Boussiotis, V.A., Chen, Z.M., Zeller, J.C., Murphy, W.J., Berezovskaya, A., Narula, S., Roncarolo, M.G., Blazar, B.R. Blood (2001)
- Maintenance of murine long-term repopulating stem cells in ex vivo culture is affected by modulation of transforming growth factor-beta but not macrophage inflammatory protein-1 alpha activities. Soma, T., Yu, J.M., Dunbar, C.E. Blood (1996)
- Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain. Wilcox, J.N., Derynck, R. J. Neurosci. (1988)
- TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Alvarez, J., Sohn, P., Zeng, X., Doetschman, T., Robbins, D.J., Serra, R. Development (2002)