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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Hemodynamic effect of endothelin antagonists in dogs with myocardial infarction.

The hemodynamic effects of enalapril, an angiotensin-converting enzyme inhibitor, BQ-123, a selective ETA receptor antagonist, and bosentan, a nonselective ETA and ETB receptor antagonist, were studied in dogs 4 weeks after myocardial infarction (MI) produced by ligation of the left anterior descending coronary artery. Reduced arterial pressure and total peripheral resistance after administration of analapril, BQ-123, and bosentan revealed that both the renin-angiotensin system and endothelin participate in maintenance of cardiovascular function in chronic MI.[1]

References

  1. Hemodynamic effect of endothelin antagonists in dogs with myocardial infarction. Ohta, H., Suzuki, J., Akima, T., Kawai, N., Hanada, K., Nishikibe, M. J. Cardiovasc. Pharmacol. (1998) [Pubmed]
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