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MeSH Review

Vascular Resistance

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Disease relevance of Vascular Resistance


Psychiatry related information on Vascular Resistance


High impact information on Vascular Resistance


Chemical compound and disease context of Vascular Resistance


Biological context of Vascular Resistance


Anatomical context of Vascular Resistance


Associations of Vascular Resistance with chemical compounds

  • The responses of blood flow and vascular resistance to acetylcholine were significantly reduced in the hypertensive patients (P less than 0.0001); maximal forearm flow was 9.1 +/- 5 ml per minute per 100 ml in the patients and 20.0 +/- 8 ml per minute per 100 ml in the controls (P less than 0.0002) [24].
  • Left ventricular filling pressure and systemic vascular resistance decreased from 23.9 to 15.3 mm Hg and from 1642 to 921, respectively, with nitroprusside, but increased to 30.4 mm Hg and 2109 (both P less than 0.001) upon its discontinuation [25].
  • However, there were no significant differences between groups in the responses of blood flow and vascular resistance to sodium nitroprusside [24].
  • The vasodilator effect of phentolamine was also significantly greater in the morning (mean decrease in vascular resistance, 38 +/- 6 percent) than in the afternoon (26 +/- 6 percent) and evening (21 +/- 7 percent) (P less than 0.05) [26].
  • RESULTS--Dopamine increased the MAP largely by increasing the cardiac index whereas norepinephrine increased the MAP by increasing the systemic vascular resistance index while maintaining the cardiac index [27].

Gene context of Vascular Resistance

  • The acute administration of an inhibitor of HO to cirrhotic rats, at a dose that normalized aortic HO activity, was associated with significantly greater effects on arterial pressure, total peripheral vascular resistance, and cardiac index, compared with effects in sham rats [28].
  • Endothelin-1 contributes to increased systemic and pulmonary vascular resistance, vascular dysfunction, myocardial ischemia and renal impairment in CHF [29].
  • Infusion of endothelin-1 (ET-1) at rates of 3, 5, or 7.5 pmol/kg/min for 7 days was associated with significant, sustained, and dose-dependent increases in mean arterial pressure and smaller less consistent elevations in total peripheral resistance [30].
  • Increased counteracting effect of eNOS and nNOS on an alpha1-adrenergic rise in total peripheral vascular resistance in spontaneous hypertensive rats [31].
  • MEASUREMENTS AND MAIN RESULTS: Administration of r-hTNF binding protein-1 resulted in improvement of mean arterial pressure, cardiac output, and systemic vascular resistance, as compared with the vehicle-treated group (p < .05) [32].

Analytical, diagnostic and therapeutic context of Vascular Resistance


  1. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. Giaid, A., Yanagisawa, M., Langleben, D., Michel, R.P., Levy, R., Shennib, H., Kimura, S., Masaki, T., Duguid, W.P., Stewart, D.J. N. Engl. J. Med. (1993) [Pubmed]
  2. Evaluation of a new bipyridine inotropic agent--milrinone--in patients with severe congestive heart failure. Baim, D.S., McDowell, A.V., Cherniles, J., Monrad, E.S., Parker, J.A., Edelson, J., Braunwald, E., Grossman, W. N. Engl. J. Med. (1983) [Pubmed]
  3. Altered platelet calcium metabolism as an early predictor of increased peripheral vascular resistance and preeclampsia in urban black women. Zemel, M.B., Zemel, P.C., Berry, S., Norman, G., Kowalczyk, C., Sokol, R.J., Standley, P.R., Walsh, M.F., Sowers, J.R. N. Engl. J. Med. (1990) [Pubmed]
  4. Systolic hypertension in the elderly. Hemodynamic response to long-term thiazide diuretic therapy and its side effects. Vardan, S., Mookherjee, S., Warner, R., Smulyan, H. JAMA (1983) [Pubmed]
  5. Inhibition of interleukin-1-alpha-induced nitric oxide synthase in vascular smooth muscle and full reversal of interleukin-1-alpha-induced hypotension by N omega-amino-L-arginine. Kilbourn, R.G., Gross, S.S., Lodato, R.F., Adams, J., Levi, R., Miller, L.L., Lachman, L.B., Griffith, O.W. J. Natl. Cancer Inst. (1992) [Pubmed]
  6. Hemodynamic effects of epinephrine: concentration-effect study in humans. Stratton, J.R., Pfeifer, M.A., Ritchie, J.L., Halter, J.B. J. Appl. Physiol. (1985) [Pubmed]
  7. Coronary physiology. Feigl, E.O. Physiol. Rev. (1983) [Pubmed]
  8. Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension. McLaughlin, V.V., Genthner, D.E., Panella, M.M., Rich, S. N. Engl. J. Med. (1998) [Pubmed]
  9. Preeclampsia -- a state of sympathetic overactivity. Schobel, H.P., Fischer, T., Heuszer, K., Geiger, H., Schmieder, R.E. N. Engl. J. Med. (1996) [Pubmed]
  10. Neurogenic coronary vasoconstrictor effects of digitalis during acute global ischemia in dogs. Sagar, K.B., Hanson, E.C., Powell, W.J. J. Clin. Invest. (1977) [Pubmed]
  11. Paracentesis-induced circulatory dysfunction: mechanism and effect on hepatic hemodynamics in cirrhosis. Ruiz-del-Arbol, L., Monescillo, A., Jimenéz, W., Garcia-Plaza, A., Arroyo, V., Rodés, J. Gastroenterology (1997) [Pubmed]
  12. Normalization of nitric oxide production corrects arterial vasodilation and hyperdynamic circulation in cirrhotic rats. Niederberger, M., Martin, P.Y., Ginès, P., Morris, K., Tsai, P., Xu, D.L., McMurtry, I., Schrier, R.W. Gastroenterology (1995) [Pubmed]
  13. Resistant hypertension: diagnosis and management. Gifford, R.W., Tarazi, R.C. Ann. Intern. Med. (1978) [Pubmed]
  14. Coronary flow regulation in patients with ischemic heart disease: release of purines and prostacyclin and the effect of inhibitors of prostaglandin formation. Edlund, A., Berglund, B., van Dorne, D., Kaijser, L., Nowak, J., Patrono, C., Sollevi, A., Wennmalm, A. Circulation (1985) [Pubmed]
  15. Thyroid hormone treatment after coronary-artery bypass surgery. Klemperer, J.D., Klein, I., Gomez, M., Helm, R.E., Ojamaa, K., Thomas, S.J., Isom, O.W., Krieger, K. N. Engl. J. Med. (1995) [Pubmed]
  16. Deleterious effects of hydralazine in patients with pulmonary hypertension. Packer, M., Greenberg, B., Massie, B., Dash, H. N. Engl. J. Med. (1982) [Pubmed]
  17. Physiologic effects of increasing hemoglobin concentration in left-to-right shunting in infants with ventricular septal defects. Lister, G., Hellenbrand, W.E., Kleinman, C.S., Talner, N.S. N. Engl. J. Med. (1982) [Pubmed]
  18. Selective beta-1 receptor blockade with oral practolol in man. A dose-related phenomenon. Lertora, J.J., Mark, A.L., Johannsen, J., Wilson, W.R., Abboud, F.M. J. Clin. Invest. (1975) [Pubmed]
  19. Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation. Ivy, D.D., Kinsella, J.P., Abman, S.H. J. Clin. Invest. (1994) [Pubmed]
  20. Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition. Pizcueta, P., Piqué, J.M., Fernández, M., Bosch, J., Rodés, J., Whittle, B.J., Moncada, S. Gastroenterology (1992) [Pubmed]
  21. Effect of antenatal betamethasone administration on placental vascular resistance. Wallace, E.M., Baker, L.S. Lancet (1999) [Pubmed]
  22. Role of a natriuretic factor in essential hypertension: an hypothesis. Blaustein, M.P., Hamlyn, J.M. Ann. Intern. Med. (1983) [Pubmed]
  23. Euthyroid hyperthyroxinemia. Borst, G.C., Eil, C., Burman, K.D. Ann. Intern. Med. (1983) [Pubmed]
  24. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. Panza, J.A., Quyyumi, A.A., Brush, J.E., Epstein, S.E. N. Engl. J. Med. (1990) [Pubmed]
  25. Rebound hemodynamic events after the abrupt withdrawal of nitroprusside in patients with severe chronic heart failure. Packer, M., Meller, J., Medina, N., Gorlin, R., Herman, M.V. N. Engl. J. Med. (1979) [Pubmed]
  26. Circadian variation in vascular tone and its relation to alpha-sympathetic vasoconstrictor activity. Panza, J.A., Epstein, S.E., Quyyumi, A.A. N. Engl. J. Med. (1991) [Pubmed]
  27. The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis. Marik, P.E., Mohedin, M. JAMA (1994) [Pubmed]
  28. Increased vascular heme oxygenase-1 expression contributes to arterial vasodilation in experimental cirrhosis in rats. Chen, Y.C., Ginès, P., Yang, J., Summer, S.N., Falk, S., Russell, N.S., Schrier, R.W. Hepatology (2004) [Pubmed]
  29. Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future? Spieker, L.E., Noll, G., Ruschitzka, F.T., Lüscher, T.F. J. Am. Coll. Cardiol. (2001) [Pubmed]
  30. Chronic hypertension produced by infusion of endothelin in rats. Mortensen, L.H., Pawloski, C.M., Kanagy, N.L., Fink, G.D. Hypertension (1990) [Pubmed]
  31. Increased counteracting effect of eNOS and nNOS on an alpha1-adrenergic rise in total peripheral vascular resistance in spontaneous hypertensive rats. Berg, T. Cardiovasc. Res. (2005) [Pubmed]
  32. Glycosylated recombinant human tumor necrosis factor binding protein-1 reduces mortality, shock, and production of tumor necrosis factor in rabbit Escherichia coli sepsis. Porat, R., Paddock, H.N., Schwaitzberg, S.D., Connolly, R.J., Wilkens, T., Dasch, J.R., Gascon, M.P., Hutchison, J.S., Ythier, A., Wallach, D. Crit. Care Med. (1995) [Pubmed]
  33. Integrated cardiac, renal, and endocrine actions of endothelin. Miller, W.L., Redfield, M.M., Burnett, J.C. J. Clin. Invest. (1989) [Pubmed]
  34. Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver. Suematsu, M., Goda, N., Sano, T., Kashiwagi, S., Egawa, T., Shinoda, Y., Ishimura, Y. J. Clin. Invest. (1995) [Pubmed]
  35. Effects of interleukin 2 on cardiac function in the isolated rat heart. Sobotka, P.A., McMannis, J., Fisher, R.I., Stein, D.G., Thomas, J.X. J. Clin. Invest. (1990) [Pubmed]
  36. Nitroglycerin as an adjunct to hypothermic hyperkalemic cardioplegia. McKeown, P.P., McClelland, J.S., Bone, D.K., Jones, E.L., Kaplan, J.A., Lutz, J.F., Hatcher, C.R., Guyton, R.A. Circulation (1983) [Pubmed]
  37. Impairment of cardiopulmonary baroreflex after cardiac transplantation in humans. Mohanty, P.K., Thames, M.D., Arrowood, J.A., Sowers, J.R., McNamara, C., Szentpetery, S. Circulation (1987) [Pubmed]
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