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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Syntheses of some new 4-chloro-2-mercapto-N(4H-1,2,4-triazol-3-yl) benzenesulphonamide with potential anticancer or anti-HIV activity.

4-Chloro-2-mercapto-5-R1-N-(4-R2-4H-1,2,4-triazol-3-yl) benzenesulphonamide [VIII-XIV] were prepared from the corresponding 4-chloro-3(R2-amino)-5-R1-1,1-dioxo-1,4, 2-benzodithiazines [I-VII] then compd. [VIII-X] were S-carboxyalkylated to the corresponding 2-¿5-chloro-4-methyl-2-[4-R2-4H-1,2,4-triazol-3-yl)aminosulphon yl] phenylthio¿alkanoic acids [XVII-XXVI]. Preliminary screening of anti HIV-1 and anticancer activity of compd. [XI,XII,XVII] was conducted.[1]

References

  1. Syntheses of some new 4-chloro-2-mercapto-N(4H-1,2,4-triazol-3-yl) benzenesulphonamide with potential anticancer or anti-HIV activity. Sławiński, J. Acta poloniae pharmaceutica. (1997) [Pubmed]
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