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Chemical Compound Review:

AG-K-59621 2-[[2-[[2-(oxiran-2- ylmethoxy)phenyl]methy...

Synonyms: AC1L1WFM, KB-16445, CTK5G9480, 54208-63-8, 58145-38-3, ...

Heiman, A.S. et al., Dainaka, J. et al., Kasuya, Y. et al., Mimura, T. et al., Kohda, I. et al., et al.

Kostoryz, Eick, Glaros, Judy, Welshons, Burmaster, Yourtee,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Diglycidyl ether of bisphenol F

Only BFDGE was mutagenic in the Ames assay with strain TA100 of Salmonella typhimurium [1].
In a sheep red blood cells (SRBC)-induced delayed-type hypersensitivity (DTH) reaction model, compd [2].
Preliminary screening of anti HIV-1 and anticancer activity of compd [3].

High impact information on Diglycidyl ether of bisphenol F

In contrast, this synergism was absent when cells were stimulated with somatostatin and compd 48/80 [4].
However, TRQ did not disturb the binding of 14C-labeled compd 48/80 to the mast cell membrane [5].
Compound 48/80 ( compd 48/80)-induced histamine secretion from rat mast cells was inhibited almost completely by pretreatment of the cells at 37 degrees with 25 microM arachidonic acid in the presence of 1.8 mM Ca2+ [6].
Cytotoxic effects of BADGE (bisphenol A diglycidyl ether) and BFDGE (bisphenol F diglycidyl ether) on Caco-2 cells in vitro [7].
The lipid peroxide level in the gastric mucosa from water immersion stressed rat was lowered by the administration of compd [8].

Biological context of Diglycidyl ether of bisphenol F

Bis[2-[(E)-2-octenoylamino]ethyl] disulfide (compd. I-3) inhibited collagen- and arachidonic acid-induced rat platelet aggregation, although not adenosine 5'-diphosphate (ADP)-induced rat platelet aggregation [9].

Anatomical context of Diglycidyl ether of bisphenol F

Therefore, we have studied the effects of PEs on purified rat peritoneal and thoracic mast cells both alone and in conjunction with the calcium ionophore, A23187, and various other secretagogues that interact with immunoglobulin E (e.g., anti-IgE and Con A) or other cell surface receptors, e.g., somatostatin and compd 48/80 [4].
Newly synthesized 1-(2',5'-dimethoxyphenyl)-1-n-butyl-3-diethylaminobutanol (compd. 4) and its analogs enhanced the antitussive effect of codeine and morphine as tested on the cough induced by mechanical stimulation of the trachea in guinea pigs [10].

Associations of Diglycidyl ether of bisphenol F with other chemical compounds

Arachidonic acid also inhibited a compd 48/80-induced spike increment of intracellular 45Ca2+ uptake and a decrease of total 45Ca2+ uptake by 45Ca2+-preloaded mast cells [6].

Analytical, diagnostic and therapeutic context of Diglycidyl ether of bisphenol F

The oral administration of compd [11].

References

Biocompatibility of hydroxylated metabolites of BISGMA and BFDGE. Kostoryz, E.L., Eick, J.D., Glaros, A.G., Judy, B.M., Welshons, W.V., Burmaster, S., Yourtee, D.M. J. Dent. Res. (2003) [Pubmed]
Inhibitory effect of bis(2-aminohexyl) disulfide and bis(2-amino-3-phenylpropyl) disulfide on several mouse inflammations. Kohama, Y., Kayamori, Y., Katayama, Y., Murayama, N., Itoh, M., Tanaka, K., Tsuboi, H., Sakaguchi, N., Mimura, T. Chem. Pharm. Bull. (1992) [Pubmed]
Syntheses of some new 4-chloro-2-mercapto-N(4H-1,2,4-triazol-3-yl) benzenesulphonamide with potential anticancer or anti-HIV activity. Sławiński, J. Acta poloniae pharmaceutica. (1997) [Pubmed]
Characterization of the effects of phorbol esters on rat mast cell secretion. Heiman, A.S., Crews, F.T. J. Immunol. (1985) [Pubmed]
Inhibitory mechanism of tritoqualine on histamine release from mast cells. Umezu, K., Yuasa, S., Ichikawa, A. Biochem. Pharmacol. (1986) [Pubmed]
Calcium dependency of inhibition by arachidonic acid of compound 48/80-induced histamine release from mast cells. Dainaka, J., Ichikawa, A., Okada, M., Tomita, K. Biochem. Pharmacol. (1984) [Pubmed]
Cytotoxic effects of BADGE (bisphenol A diglycidyl ether) and BFDGE (bisphenol F diglycidyl ether) on Caco-2 cells in vitro. Ramilo, G., Valverde, I., Lago, J., Vieites, J.M., Cabado, A.G. Arch. Toxicol. (2006) [Pubmed]
Further studies on the anti-ulcerogenic effects of compound, 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide. Kohda, I., Nagai, H., Iwai, M., Watanabe, M., Yokoyama, K., Tsujikawa, K., Mimura, T. Chem. Pharm. Bull. (1991) [Pubmed]
The inhibitory effect of bis[2-[(E)-2-octenoylamino]ethyl] disulfide on the cyclooxygenase pathway. Mimura, T., Nakajima, H., Tsujikawa, K., Yasuda, N., Haruyama, M., Okabe, M., Iwai, M., Yokoyama, K. Chem. Pharm. Bull. (1989) [Pubmed]
Potentiation of antitussive effect of codeine by some 1-dimethoxyphenyl-3-alkylaminobutanols in guinea pigs. Kasuya, Y., Watanabe, M., Miyasaka, K., Ishii, Y. Arzneimittel-Forschung. (1977) [Pubmed]
Effects of 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide on various ulcer models in rats. Kohda, I., Nagai, H., Iwai, M., Watanabe, M., Yokoyama, K., Tsujikawa, K., Mimura, T. Chem. Pharm. Bull. (1991) [Pubmed]

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