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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Enzymatic amplification and expression of bovine interleukin-1 receptor antagonist cDNA.

cDNA generated from lipopolysaccharide-stimulated bovine peripheral blood mononuclear cells was used to amplify and clone the bovine interleukin-1 receptor antagonist (IL-1ra) using primers derived from semi-conserved regions between human and mouse IL-1ra sequences. 5' and 3' terminal sequences of bovine IL-1ra were amplified by 5' and 3' rapid amplification of cDNA ends. The deduced amino acid sequence of bovine IL-1ra demonstrated 80%, 78%, 78%, 77% and 76% homology with human, mouse, rat, rabbit and equine sequences, respectively. Recombinant bovine IL-1ra produced in Escherichia coli suppressed the growth inhibitory activity of bovine IL-1beta on A375 cells in a dose-dependent manner, indicating that the present bovine IL-1ra cDNA encodes biologically active proteins.[1]


  1. Enzymatic amplification and expression of bovine interleukin-1 receptor antagonist cDNA. Kirisawa, R., Fukuda, T., Yamanaka, H., Hagiwara, K., Goto, M., Obata, Y., Yoshino, T., Iwai, H. Vet. Immunol. Immunopathol. (1998) [Pubmed]
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