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Chemical Compound Review

Lipopolysaccharide     (2R,5S)-5-[(2R,3R,5R)-4- [(2R,3R,5R)-4-[(2R...

Synonyms:
 
 
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Disease relevance of Lipopolysaccharide

 

Psychiatry related information on Lipopolysaccharide

 

High impact information on Lipopolysaccharide

  • Finally, we show that abnormal immunity in OL-EDA-ID patients results from impaired cell responses to lipopolysaccharide, interleukin (IL)-1beta, IL-18, TNFalpha and CD154 [10].
  • Subcellular fractionation of LPS-stimulated macrophages revealed that LPS signals transduced by Tpl2 specifically promote the transport of TNF-alpha mRNA from the nucleus to the cytoplasm [11].
  • Transfection of THP-1 cells demonstrates that the Asp299Gly mutation (but not the Thr399Ile mutation) interrupts TLR4-mediated LPS signalling [12].
  • Moreover, the wild-type allele of TLR4 rescues the LPS hyporesponsive phenotype in either primary airway epithelial cells or alveolar macrophages obtained from individuals with the TLR4 mutations [12].
  • Here we show that common, co-segregating missense mutations (Asp299Gly and Thr399Ile) affecting the extracellular domain of the TLR4 receptor are associated with a blunted response to inhaled LPS in humans [12].
 

Chemical compound and disease context of Lipopolysaccharide

 

Biological context of Lipopolysaccharide

 

Anatomical context of Lipopolysaccharide

 

Associations of Lipopolysaccharide with other chemical compounds

  • Moreover, upregulation of epithelial C3 production by stimulation with lipopolysaccharide enhanced bacterial internalization [26].
  • Lithium chloride induces partial responsiveness to LPS in nonresponder B cells [27].
  • Acetylcholine, the principle vagal neurotransmitter, significantly attenuated the release of cytokines (tumour necrosis factor (TNF), interleukin (IL)-1beta, IL-6 and IL-18), but not the anti-inflammatory cytokine IL-10, in lipopolysaccharide-stimulated human macrophage cultures [28].
  • Macrophages can bind, internalize and partially degrade LPS, lipid A and its bioactive precursor, lipid IVA [29].
  • Proliferation of memory-phenotype (CD44hi) CD8+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I-inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent [30].
 

Gene context of Lipopolysaccharide

 

Analytical, diagnostic and therapeutic context of Lipopolysaccharide

References

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