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Chemical Compound Review

Lipopolysaccharide     (2R,5S)-5-[(2R,3R,5R)-4- [(2R,3R,5R)-4-[(2R...

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Disease relevance of Lipopolysaccharide


Psychiatry related information on Lipopolysaccharide


High impact information on Lipopolysaccharide

  • Finally, we show that abnormal immunity in OL-EDA-ID patients results from impaired cell responses to lipopolysaccharide, interleukin (IL)-1beta, IL-18, TNFalpha and CD154 [10].
  • Subcellular fractionation of LPS-stimulated macrophages revealed that LPS signals transduced by Tpl2 specifically promote the transport of TNF-alpha mRNA from the nucleus to the cytoplasm [11].
  • Transfection of THP-1 cells demonstrates that the Asp299Gly mutation (but not the Thr399Ile mutation) interrupts TLR4-mediated LPS signalling [12].
  • Moreover, the wild-type allele of TLR4 rescues the LPS hyporesponsive phenotype in either primary airway epithelial cells or alveolar macrophages obtained from individuals with the TLR4 mutations [12].
  • Here we show that common, co-segregating missense mutations (Asp299Gly and Thr399Ile) affecting the extracellular domain of the TLR4 receptor are associated with a blunted response to inhaled LPS in humans [12].

Chemical compound and disease context of Lipopolysaccharide


Biological context of Lipopolysaccharide


Anatomical context of Lipopolysaccharide


Associations of Lipopolysaccharide with other chemical compounds

  • Moreover, upregulation of epithelial C3 production by stimulation with lipopolysaccharide enhanced bacterial internalization [26].
  • Lithium chloride induces partial responsiveness to LPS in nonresponder B cells [27].
  • Acetylcholine, the principle vagal neurotransmitter, significantly attenuated the release of cytokines (tumour necrosis factor (TNF), interleukin (IL)-1beta, IL-6 and IL-18), but not the anti-inflammatory cytokine IL-10, in lipopolysaccharide-stimulated human macrophage cultures [28].
  • Macrophages can bind, internalize and partially degrade LPS, lipid A and its bioactive precursor, lipid IVA [29].
  • Proliferation of memory-phenotype (CD44hi) CD8+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I-inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent [30].

Gene context of Lipopolysaccharide


Analytical, diagnostic and therapeutic context of Lipopolysaccharide


  1. Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli. Ziegler, E.J., McCutchan, J.A., Fierer, J., Glauser, M.P., Sadoff, J.C., Douglas, H., Braude, A.I. N. Engl. J. Med. (1982) [Pubmed]
  2. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Wang, S., Miura, M., Jung, Y.K., Zhu, H., Li, E., Yuan, J. Cell (1998) [Pubmed]
  3. Circular DNA is excised by immunoglobulin class switch recombination. Iwasato, T., Shimizu, A., Honjo, T., Yamagishi, H. Cell (1990) [Pubmed]
  4. Yersinia antigens in synovial-fluid cells from patients with reactive arthritis. Granfors, K., Jalkanen, S., von Essen, R., Lahesmaa-Rantala, R., Isomäki, O., Pekkola-Heino, K., Merilahti-Palo, R., Saario, R., Isomäki, H., Toivanen, A. N. Engl. J. Med. (1989) [Pubmed]
  5. Shared idiotypes among monoclonal antibodies specific for different immunodominant sugars of lipopolysaccharide of different Gram-negative bacteria. Hiernaux, J., Bona, C.A. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  6. Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease. Baker, C.A., Manuelidis, L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Intraportal lipopolysaccharide suppresses pulmonary antibacterial defense mechanisms. Mason, C.M., Dobard, E., Summer, W.R., Nelson, S. J. Infect. Dis. (1997) [Pubmed]
  8. The effects of acute and chronic alcoholism on tumor necrosis factor and the inflammatory response. Nelson, S., Bagby, G.J., Bainton, B.G., Summer, W.R. J. Infect. Dis. (1989) [Pubmed]
  9. Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice. DiCarlo, G., Wilcock, D., Henderson, D., Gordon, M., Morgan, D. Neurobiol. Aging (2001) [Pubmed]
  10. X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling. Döffinger, R., Smahi, A., Bessia, C., Geissmann, F., Feinberg, J., Durandy, A., Bodemer, C., Kenwrick, S., Dupuis-Girod, S., Blanche, S., Wood, P., Rabia, S.H., Headon, D.J., Overbeek, P.A., Le Deist, F., Holland, S.M., Belani, K., Kumararatne, D.S., Fischer, A., Shapiro, R., Conley, M.E., Reimund, E., Kalhoff, H., Abinun, M., Munnich, A., Israël, A., Courtois, G., Casanova, J.L. Nat. Genet. (2001) [Pubmed]
  11. TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Dumitru, C.D., Ceci, J.D., Tsatsanis, C., Kontoyiannis, D., Stamatakis, K., Lin, J.H., Patriotis, C., Jenkins, N.A., Copeland, N.G., Kollias, G., Tsichlis, P.N. Cell (2000) [Pubmed]
  12. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Arbour, N.C., Lorenz, E., Schutte, B.C., Zabner, J., Kline, J.N., Jones, M., Frees, K., Watt, J.L., Schwartz, D.A. Nat. Genet. (2000) [Pubmed]
  13. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Lee, E.G., Boone, D.L., Chai, S., Libby, S.L., Chien, M., Lodolce, J.P., Ma, A. Science (2000) [Pubmed]
  14. Anthrax toxin blocks priming of neutrophils by lipopolysaccharide and by muramyl dipeptide. Wright, G.G., Mandell, G.L. J. Exp. Med. (1986) [Pubmed]
  15. Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice. Lehmann, V., Freudenberg, M.A., Galanos, C. J. Exp. Med. (1987) [Pubmed]
  16. Characterization of a membrane pore-forming protein from Entamoeba histolytica. Young, J.D., Young, T.M., Lu, L.P., Unkeless, J.C., Cohn, Z.A. J. Exp. Med. (1982) [Pubmed]
  17. Phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive protein. Weiser, J.N., Pan, N., McGowan, K.L., Musher, D., Martin, A., Richards, J. J. Exp. Med. (1998) [Pubmed]
  18. Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Sen, R., Baltimore, D. Cell (1986) [Pubmed]
  19. The role of the kappa enhancer and its binding factor NF-kappa B in the developmental regulation of kappa gene transcription. Atchison, M.L., Perry, R.P. Cell (1987) [Pubmed]
  20. Mitogen- and IL-4-regulated expression of germ-line Ig gamma 2b transcripts: evidence for directed heavy chain class switching. Lutzker, S., Rothman, P., Pollock, R., Coffman, R., Alt, F.W. Cell (1988) [Pubmed]
  21. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Gu, H., Zou, Y.R., Rajewsky, K. Cell (1993) [Pubmed]
  22. B lymphocyte receptors and polyphosphoinositide degradation. Bijsterbosch, M.K., Meade, C.J., Turner, G.A., Klaus, G.G. Cell (1985) [Pubmed]
  23. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Kelly, K., Cochran, B.H., Stiles, C.D., Leder, P. Cell (1983) [Pubmed]
  24. Clonal growth and maturation to immunoglobulin secretion in vitro of every growth-inducible B lymphocyte. Andersson, J., Coutinho, A., Lernhardt, W., Melchers, F. Cell (1977) [Pubmed]
  25. Protection against cholera in breast-fed children by antibodies in breast milk. Glass, R.I., Svennerholm, A.M., Stoll, B.J., Khan, M.R., Hossain, K.M., Huq, M.I., Holmgren, J. N. Engl. J. Med. (1983) [Pubmed]
  26. Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli. Springall, T., Sheerin, N.S., Abe, K., Holers, V.M., Wan, H., Sacks, S.H. Nat. Med. (2001) [Pubmed]
  27. Lithium chloride induces partial responsiveness to LPS in nonresponder B cells. Ishizaka, S., Möller, G. Nature (1982) [Pubmed]
  28. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Borovikova, L.V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G.I., Watkins, L.R., Wang, H., Abumrad, N., Eaton, J.W., Tracey, K.J. Nature (2000) [Pubmed]
  29. Recognition and plasma clearance of endotoxin by scavenger receptors. Hampton, R.Y., Golenbock, D.T., Penman, M., Krieger, M., Raetz, C.R. Nature (1991) [Pubmed]
  30. Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Zhang, X., Sun, S., Hwang, I., Tough, D.F., Sprent, J. Immunity (1998) [Pubmed]
  31. Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction. Robertson, N.G., Lu, L., Heller, S., Merchant, S.N., Eavey, R.D., McKenna, M., Nadol, J.B., Miyamoto, R.T., Linthicum, F.H., Lubianca Neto, J.F., Hudspeth, A.J., Seidman, C.E., Morton, C.C., Seidman, J.G. Nat. Genet. (1998) [Pubmed]
  32. Human CD14 mediates recognition and phagocytosis of apoptotic cells. Devitt, A., Moffatt, O.D., Raykundalia, C., Capra, J.D., Simmons, D.L., Gregory, C.D. Nature (1998) [Pubmed]
  33. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Lee, T.S., Chau, L.Y. Nat. Med. (2002) [Pubmed]
  34. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Yang, R.B., Mark, M.R., Gray, A., Huang, A., Xie, M.H., Zhang, M., Goddard, A., Wood, W.I., Gurney, A.L., Godowski, P.J. Nature (1998) [Pubmed]
  35. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Minty, A., Chalon, P., Derocq, J.M., Dumont, X., Guillemot, J.C., Kaghad, M., Labit, C., Leplatois, P., Liauzun, P., Miloux, B. Nature (1993) [Pubmed]
  36. V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling. Hertz, M., Kouskoff, V., Nakamura, T., Nemazee, D. Nature (1998) [Pubmed]
  37. Stress-induced modulation of the immune response. Monjan, A.A., Collector, M.I. Science (1977) [Pubmed]
  38. TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Toshchakov, V., Jones, B.W., Perera, P.Y., Thomas, K., Cody, M.J., Zhang, S., Williams, B.R., Major, J., Hamilton, T.A., Fenton, M.J., Vogel, S.N. Nat. Immunol. (2002) [Pubmed]
  39. A CD14-independent LPS receptor cluster. Triantafilou, K., Triantafilou, M., Dedrick, R.L. Nat. Immunol. (2001) [Pubmed]
  40. Bacterial endotoxin (lipopolysaccharide) as a cause of erythema multiforme. Shelley, W.B. JAMA (1980) [Pubmed]
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