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Gene Review

IL1RN  -  interleukin 1 receptor antagonist

Bos taurus

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Disease relevance of IL1RN

  • Recombinant bovine IL-1ra produced in Escherichia coli suppressed the growth inhibitory activity of bovine IL-1beta on A375 cells in a dose-dependent manner, indicating that the present bovine IL-1ra cDNA encodes biologically active proteins [1].
  • The results are consistent with the assumption that BLV infection leads to the production and secretion of a soluble IL-1 inhibitor by LPS-stimulated peripheral blood monocytes [2].

High impact information on IL1RN

  • Likewise, blocking the IL-1 type 1 receptor by addition of IL-receptor antagonist (IL-1ra) significantly enhanced LOS-mediated caspase-3 activation [3].
  • OBJECTIVE: To test the in vivo effects of interleukin 1 receptor antagonist (IL-1ra) on bone formation and tissue ingrowth using an implantable bone ingrowth chamber that can be infused with test solutions [4].
  • After an initial osseointegration period, the chambers were emptied of tissue and infused with either 0.05% bovine serum albumin (BSA) in phosphate buffered saline (PBS) or an IL-1ra solution for 4-week periods, which were separated by 4-week periods of no infusion [4].
  • Pretreatment of PBMC from newborn calves with IL-1beta, TNF-alpha or IFN-gamma significantly enhanced the ConA response, whereas IL-1ra inhibited the response [5].
  • Incubation of PMNs with LPS up-regulated IL-1beta gene expression, whereas, IL-1alpha, IL-1ra, type 2 IL-1R and ICE were unchanged [6].

Biological context of IL1RN


Anatomical context of IL1RN

  • A positive correlation was observed between the concentrations of IL-1ra and IL-1 beta in the colostrum samples [7].
  • The expression of mRNA for IL-1 receptor antagonist (IL-1ra) was demonstrated by reverse transcription-polymerase chain reaction in bovine mammary epithelial cells [9].

Associations of IL1RN with chemical compounds


Other interactions of IL1RN

  • Messenger RNA (mRNA) transcript levels for the IL2, IL8, and IL1RN genes were significantly downregulated across the time course of infection in both breeds [10].

Analytical, diagnostic and therapeutic context of IL1RN

  • Gene expression of mRNA for IL-1alpha, IL-1beta, IL-1 receptor antagonist (IL-1ra), type 1 IL-1 receptor, type 2 IL-1 receptor, and IL-1 beta converting enzyme (ICE), were measured by a semi-quantitative RT-PCR technique [6].


  1. Enzymatic amplification and expression of bovine interleukin-1 receptor antagonist cDNA. Kirisawa, R., Fukuda, T., Yamanaka, H., Hagiwara, K., Goto, M., Obata, Y., Yoshino, T., Iwai, H. Vet. Immunol. Immunopathol. (1998) [Pubmed]
  2. Effect of bovine leukemia virus infection on bovine peripheral blood monocyte responsiveness to lipopolysaccharide stimulation in vitro. Werling, D., Sileghem, M., Lutz, H., Langhans, W. Vet. Immunol. Immunopathol. (1995) [Pubmed]
  3. Signaling through interleukin-1 type 1 receptor diminishes Haemophilus somnus lipooligosaccharide-mediated apoptosis of endothelial cells. Sylte, M.J., Kuckleburg, C.J., Atapattu, D., Leite, F.P., McClenahan, D., Inzana, T.J., Czuprynski, C.J. Microb. Pathog. (2005) [Pubmed]
  4. Interleukin 1 receptor antagonist inhibits localized bone formation in vivo. Ma, T., Miyanishi, K., Trindade, M.C., Genovese, M., Regula, D., Smith, R.L., Goodman, S.B. J. Rheumatol. (2003) [Pubmed]
  5. Proinflammatory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression. Yamanaka, H., Hagiwara, K., Kirisawa, R., Iwai, H. Microbiol. Immunol. (2003) [Pubmed]
  6. Differential gene regulation of interleukin-1 ligands and receptors in bovine peripheral blood neutrophils and mononuclear cells in response to E. coli lipopolysaccharide (LPS). Beckman, M.J., Sotos, J., Leite, F., Schuler, L.A., Czuprynski, C.J. Vet. Immunol. Immunopathol. (2000) [Pubmed]
  7. Detection of cytokines in bovine colostrum. Hagiwara, K., Kataoka, S., Yamanaka, H., Kirisawa, R., Iwai, H. Vet. Immunol. Immunopathol. (2000) [Pubmed]
  8. Effects of EDTA-induced hypocalcaemia and stress on plasma TNF-alpha, IL-1-ra, G-CSF, GM-CSF and S-100 in dairy cows. Riond, J.L., Liesegang, A., Wanner, M., Kaiser, C., Döbeli, M., Joller-Jemelka, H.I. Vet. Res. Commun. (1999) [Pubmed]
  9. Effects of lipopolysaccharide on production of interleukin-1 and interleukin-6 by bovine mammary epithelial cells in vitro. Okada, H., Ohtsuka, H., Kon Nai, S., Kirisawa, R., Yokomizo, Y., Yoshino, T., Rosol, T.J. J. Vet. Med. Sci. (1999) [Pubmed]
  10. Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense. O'Gorman, G.M., Park, S.D., Hill, E.W., Meade, K.G., Mitchell, L.C., Agaba, M., Gibson, J.P., Hanotte, O., Naessens, J., Kemp, S.J., MacHugh, D.E. Physiol. Genomics (2006) [Pubmed]
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