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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain.

An aggrecan G1- G2 substrate was used to determine sites within the interglobular domain that were susceptible to cleavage by MT1-MMP. Degradation products were identified by Western blotting with neo-epitope antibodies specific for MMP-derived N- and C-terminal sequences. The results showed that MT1-MMP cleaved at the N341-F342 and D441-L442 bonds, as shown for other MMPs, and also at a site 13 amino acids C-terminal to the N341-F342 site. The G2 product of this additional cleavage was identified by sequence analysis and revealed an N-terminus commencing T355VxxPDVELPLP. The data are consistent with MT1-MMP cleavage at three sites in the aggrecan interglobular domain; one at N342-F342, a second at D441-L442 and a third at Q354-T355.[1]


  1. Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain. Fosang, A.J., Last, K., Fujii, Y., Seiki, M., Okada, Y. FEBS Lett. (1998) [Pubmed]
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