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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A dopaminergic mechanism in mania.

The authors present a case study that explores the relationship of dopamine function and manic illness through the use of two drugs with relatively specific effects in stimulating and blocking dopamine receptors--piribedil (ET--495) and pimozide, respectively. Piribedil, as well as d-amphetamine, was associated with manic episodes, while pimozide had an antimanic effect. These observations suggest that dopaminergic mechanisms may be involved in the mediation of manic episodes in at least some patients.[1]


  1. A dopaminergic mechanism in mania. Gerner, R.H., Post, R.M., Bunney, W.E. The American journal of psychiatry. (1976) [Pubmed]
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