- Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa. Phillips, G.B., Buckman, B.O., Davey, D.D., Eagen, K.A., Guilford, W.J., Hinchman, J., Ho, E., Koovakkat, S., Liang, A., Light, D.R., Mohan, R., Ng, H.P., Post, J.M., Shaw, K.J., Smith, D., Subramanyam, B., Sullivan, M.E., Trinh, L., Vergona, R., Walters, J., White, K., Whitlow, M., Wu, S., Xu, W., Morrissey, M.M. J. Med. Chem. (1998)