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MeSH Review

Blood Coagulation

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Disease relevance of Blood Coagulation

  • Egr-1 DNAzymes suppressed tumor growth without influencing body weight, wound healing, blood coagulation or other hematological parameters [1].
  • Fluorescently labeled mouse microparticles infused into a recipient mouse localized within the developing thrombus, indicating that one pathway for the initiation of blood coagulation in vivo involves the accumulation of tissue factor- and PSGL-1-containing microparticles in the platelet thrombus expressing P-selectin [2].
  • In contrast, C1-INH administration prevented endotoxin-induced hypoxemia, the increase in intrapulmonary shunt, and the decrease in blood coagulation contact factors [3].
  • Several studies have established a link between blood coagulation and cancer, and more specifically between tissue factor (TF), a transmembrane protein involved in initiating blood coagulation, and tumor metastasis [4].
  • This suggests that the viral protein may possess a similar biological activity, which may enable it to effect hemorrhage by inhibiting one or more of the serine proteases involved in the host's normal processes of blood coagulation and wound containment [5].

Psychiatry related information on Blood Coagulation


High impact information on Blood Coagulation


Chemical compound and disease context of Blood Coagulation


Biological context of Blood Coagulation


Anatomical context of Blood Coagulation


Associations of Blood Coagulation with chemical compounds


Gene context of Blood Coagulation


Analytical, diagnostic and therapeutic context of Blood Coagulation


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  2. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. Falati, S., Liu, Q., Gross, P., Merrill-Skoloff, G., Chou, J., Vandendries, E., Celi, A., Croce, K., Furie, B.C., Furie, B. J. Exp. Med. (2003) [Pubmed]
  3. Endotoxin-induced pulmonary dysfunction is prevented by C1-esterase inhibitor. Guerrero, R., Velasco, F., Rodriguez, M., Lopez, A., Rojas, R., Alvarez, M.A., Villalba, R., Rubio, V., Torres, A., del Castillo, D. J. Clin. Invest. (1993) [Pubmed]
  4. Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation. Bromberg, M.E., Konigsberg, W.H., Madison, J.F., Pawashe, A., Garen, A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  5. Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases. Pickup, D.J., Ink, B.S., Hu, W., Ray, C.A., Joklik, W.K. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  6. Clinical genetics issues encountered by family physicians. Acheson, L.S., Stange, K.C., Zyzanski, S. Genet. Med. (2005) [Pubmed]
  7. Biochemistry and genetics of von Willebrand factor. Sadler, J.E. Annu. Rev. Biochem. (1998) [Pubmed]
  8. Activation of coagulation after administration of tumor necrosis factor to normal subjects. van der Poll, T., Büller, H.R., ten Cate, H., Wortel, C.H., Bauer, K.A., van Deventer, S.J., Hack, C.E., Sauerwein, H.P., Rosenberg, R.D., ten Cate, J.W. N. Engl. J. Med. (1990) [Pubmed]
  9. Defective propeptide processing of blood clotting factor IX caused by mutation of arginine to glutamine at position -4. Bentley, A.K., Rees, D.J., Rizza, C., Brownlee, G.G. Cell (1986) [Pubmed]
  10. Congenital protein C deficiency and venous thromboembolism. A study of three Dutch families. Broekmans, A.W., Veltkamp, J.J., Bertina, R.M. N. Engl. J. Med. (1983) [Pubmed]
  11. Cross-linking of a major fibroblast surface-associated glycoprotein (fibronectin) catalyzed by blood coagulation factor XIII. Keski-Oja, J., Mosher, D.F., Vaheri, A. Cell (1976) [Pubmed]
  12. Effect of aspirin and sodium salicylate on thrombosis, fibrinolysis, prothrombin time, and platelet survival In rabbits with indwelling aortic catheters. Cattaneo, M., Chahil, A., Somers, D., Kinlough-Rathbone, R.L., Packham, M.A., Mustard, J.F. Blood (1983) [Pubmed]
  13. X-ray diffraction analyses of crystals of rat liver NAD(P)H:(quinone-acceptor) oxidoreductase containing cibacron blue. Ysern, X., Prochaska, H.J. J. Biol. Chem. (1989) [Pubmed]
  14. Safety of antioxidant vitamins and beta-carotene. Diplock, A.T. Am. J. Clin. Nutr. (1995) [Pubmed]
  15. The contact phase of blood coagulation and renin activation in essential hypertension before and after captopril. Patrassi, G.M., Fallo, F., Martinelli, S., Mantero, F., Boeri, G., Girolami, A. Eur. Heart J. (1984) [Pubmed]
  16. Acceleration of tumor growth and peri-tumoral blood clotting by imatinib mesylate (Gleevec). Samoszuk, M., Corwin, M.A. Int. J. Cancer (2003) [Pubmed]
  17. Surface activation of blood coagulation, fibrinolysis and kinin formation. Heimark, R.L., Kurachi, K., Fujikawa, K., Davie, E.W. Nature (1980) [Pubmed]
  18. A subfamily of P-type ATPases with aminophospholipid transporting activity. Tang, X., Halleck, M.S., Schlegel, R.A., Williamson, P. Science (1996) [Pubmed]
  19. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Simmons, D.L., Botting, R.M., Hla, T. Pharmacol. Rev. (2004) [Pubmed]
  20. Acute heat stroke. Epidemiologic, biochemical, renal, and coagulation studies. O'Donnell, T.F. JAMA (1975) [Pubmed]
  21. The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation. Cummings, S.R., Eckert, S., Krueger, K.A., Grady, D., Powles, T.J., Cauley, J.A., Norton, L., Nickelsen, T., Bjarnason, N.H., Morrow, M., Lippman, M.E., Black, D., Glusman, J.E., Costa, A., Jordan, V.C. JAMA (1999) [Pubmed]
  22. Tissue factor gene localized to human chromosome 1 (1pter----1p21). Carson, S.D., Henry, W.M., Shows, T.B. Science (1985) [Pubmed]
  23. Complete antithrombin deficiency in mice results in embryonic lethality. Ishiguro, K., Kojima, T., Kadomatsu, K., Nakayama, Y., Takagi, A., Suzuki, M., Takeda, N., Ito, M., Yamamoto, K., Matsushita, T., Kusugami, K., Muramatsu, T., Saito, H. J. Clin. Invest. (2000) [Pubmed]
  24. Evidence for time-dependent activation of monocytes in the systemic circulation in unstable angina but not in acute myocardial infarction or in stable angina. Jude, B., Agraou, B., McFadden, E.P., Susen, S., Bauters, C., Lepelley, P., Vanhaesbroucke, C., Devos, P., Cosson, A., Asseman, P. Circulation (1994) [Pubmed]
  25. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Stearns-Kurosawa, D.J., Kurosawa, S., Mollica, J.S., Ferrell, G.L., Esmon, C.T. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  26. Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity. Higgs, G.A., Salmon, J.A., Henderson, B., Vane, J.R. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  27. Heparin-like inhibitor of blood coagulation in normal newborn. Muller, A.D., van Doorm, J.M., Hemker, H.C. Nature (1977) [Pubmed]
  28. Generation of beta-globin by sequence-specific proteolysis of a hybrid protein produced in Escherichia coli. Nagai, K., Thøgersen, H.C. Nature (1984) [Pubmed]
  29. Effect of warfarin on survival in small cell carcinoma of the lung. Veterans Administration Study No. 75. Zacharski, L.R., Henderson, W.G., Rickles, F.R., Forman, W.B., Cornell, C.J., Forcier, R.J., Edwards, R., Headley, E., Kim, S.H., O'Donnell, J.R., O'Dell, R., Tornyos, K., Kwaan, H.C. JAMA (1981) [Pubmed]
  30. Blood clotting and cholesterol crystal embolization. Oster, P., Rieben, F.W., Waldherr, R., Schettler, G. JAMA (1979) [Pubmed]
  31. Multiple sedimenting species of properdin in human serum and interaction of purified properdin with the third component of complement. Chapitis, J., Lepow, I.H. J. Exp. Med. (1976) [Pubmed]
  32. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Levy, G.G., Nichols, W.C., Lian, E.C., Foroud, T., McClintick, J.N., McGee, B.M., Yang, A.Y., Siemieniak, D.R., Stark, K.R., Gruppo, R., Sarode, R., Shurin, S.B., Chandrasekaran, V., Stabler, S.P., Sabio, H., Bouhassira, E.E., Upshaw, J.D., Ginsburg, D., Tsai, H.M. Nature (2001) [Pubmed]
  33. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Isermann, B., Sood, R., Pawlinski, R., Zogg, M., Kalloway, S., Degen, J.L., Mackman, N., Weiler, H. Nat. Med. (2003) [Pubmed]
  34. Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells. Anderson, H.A., Maylock, C.A., Williams, J.A., Paweletz, C.P., Shu, H., Shacter, E. Nat. Immunol. (2003) [Pubmed]
  35. Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor. Fukudome, K., Ye, X., Tsuneyoshi, N., Tokunaga, O., Sugawara, K., Mizokami, H., Kimoto, M. J. Exp. Med. (1998) [Pubmed]
  36. A novel degradation pathway of tissue factor pathway inhibitor: incorporation into fibrin clot and degradation by thrombin. Ohkura, N., Enjyoji, K., Kamikubo, Y., Kato, H. Blood (1997) [Pubmed]
  37. Mg(II) binding by bovine prothrombin fragment 1 via equilibrium dialysis and the relative roles of Mg(II) and Ca(II) in blood coagulation. Deerfield, D.W., Olson, D.L., Berkowitz, P., Byrd, P.A., Koehler, K.A., Pedersen, L.G., Hiskey, R.G. J. Biol. Chem. (1987) [Pubmed]
  38. Role of lipopolysaccharide and cecal ligation and puncture on blood coagulation and inflammation in sensitive and resistant mice models. Corral, J., Yélamos, J., Hernández-Espinosa, D., Monreal, Y., Mota, R., Arcas, I., Miñano, A., Parrilla, P., Vicente, V. Am. J. Pathol. (2005) [Pubmed]
  39. Mutagenesis of the gamma-carboxyglutamic acid domain of human factor VII to generate maximum enhancement of the membrane contact site. Harvey, S.B., Stone, M.D., Martinez, M.B., Nelsestuen, G.L. J. Biol. Chem. (2003) [Pubmed]
  40. Identification of the calcium binding site and a novel ytterbium site in blood coagulation factor XIII by x-ray crystallography. Fox, B.A., Yee, V.C., Pedersen, L.C., Le Trong, I., Bishop, P.D., Stenkamp, R.E., Teller, D.C. J. Biol. Chem. (1999) [Pubmed]
  41. A novel trypsin inhibitor from the hemolymph of the horseshoe crab Limulus polyphemus. Donovan, M.A., Laue, T.M. J. Biol. Chem. (1991) [Pubmed]
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