Chemical Compound Review:
SureCN1649552 2-[[2-[[3- (diaminomethylidene)-6-oxo- 1...
Synonyms:
FT-0668536, AC1O5FK6
Chi,
Pen,
Potoczak,
Gibson,
Hicks,
Mertz,
Janiczek,
Juneau,
Gallagher,
Leadley,
Post,
Sullivan,
Abendschein,
Ewing,
Hinchman,
Light,
Abendschein,
Baum,
Verhallen,
Eisenberg,
Sullivan,
Light,
McLean,
Schirm,
Johns,
Morser,
Light,
McClanahan,
Hicks,
Morrison,
Peng,
Janiczek-Dolphin,
Mertz,
Sullivan,
Morser,
Juneau,
Leadley,
Abendschein,
Baum,
Martin,
Vergona,
Post,
Rumennik,
Sullivan,
Eisenberg,
Light,
- The antithrombotic effects of CI-1031 (ZK-807834) and enoxaparin in a canine electrolytic injury model of arterial and venous thrombosis. McClanahan, T.B., Hicks, G.W., Morrison, A.L., Peng, Y.W., Janiczek-Dolphin, N., Mertz, T.E., Sullivan, M.E., Morser, J., Juneau, P.L., Leadley, R. Eur. J. Pharmacol. (2001)
- Assessment of ex vivo pharmacodynamic markers during inhibition of thrombosis by CI-1031 (ZK-807834), a novel direct factor Xa inhibitor. Chi, L., Pen, Y.W., Potoczak, R., Gibson, G., Hicks, G., Mertz, T.E., Janiczek, N., Juneau, P.L., Gallagher, K., Leadley, R. Pharmacology (2002)
- FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834. McLean, K., Schirm, S., Johns, A., Morser, J., Light, D.R. Thromb. Res. (2001)
- Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa. Adler, M., Davey, D.D., Phillips, G.B., Kim, S.H., Jancarik, J., Rumennik, G., Light, D.R., Whitlow, M. Biochemistry (2000)
- Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa. Phillips, G.B., Buckman, B.O., Davey, D.D., Eagen, K.A., Guilford, W.J., Hinchman, J., Ho, E., Koovakkat, S., Liang, A., Light, D.R., Mohan, R., Ng, H.P., Post, J.M., Shaw, K.J., Smith, D., Subramanyam, B., Sullivan, M.E., Trinh, L., Vergona, R., Walters, J., White, K., Whitlow, M., Wu, S., Xu, W., Morrissey, M.M. J. Med. Chem. (1998)
- A novel synthetic inhibitor of factor Xa decreases early reocclusion and improves 24-h patency after coronary fibrinolysis in dogs. Abendschein, D.R., Baum, P.K., Verhallen, P., Eisenberg, P.R., Sullivan, M.E., Light, D.R. J. Pharmacol. Exp. Ther. (2001)
- Human in vitro pharmacodynamic profile of the selective Factor Xa inhibitor ZK-807834 (CI-1031). Post, J.M., Sullivan, M.E., Abendschein, D., Ewing, J., Hinchman, J.W., Light, D.R. Thromb. Res. (2002)
- Effects of ZK-807834, a novel inhibitor of factor Xa, on arterial and venous thrombosis in rabbits. Abendschein, D.R., Baum, P.K., Martin, D.J., Vergona, R., Post, J., Rumennik, G., Sullivan, M.E., Eisenberg, P.R., Light, D.R. J. Cardiovasc. Pharmacol. (2000)