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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

5-HT1-like receptors: a time to bid goodbye.

It is exactly half a century ago that 5-hydroxytryptamine was discovered and over four decades ago two types of 5-HT receptors were described. In this article, Pramod Saxena, Peter De Vries and Carlos Villalón trace the development of the modern classification and nomenclature of 5-HT receptors, which now include more than a dozen subtypes. In doing so, they advocate that the so-called '5-HT1-like' receptors, having been shown to be a heterogeneous population of 5-HT1B, 5-HT1D and 5-HT7 receptors, are now redundant.[1]


  1. 5-HT1-like receptors: a time to bid goodbye. Saxena, P.R., De Vries, P., Villalón, C.M. Trends Pharmacol. Sci. (1998) [Pubmed]
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