The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

HTR7  -  5-hydroxytryptamine (serotonin) receptor 7...

Homo sapiens

Synonyms: 5-HT-7, 5-HT-X, 5-HT7, 5-hydroxytryptamine receptor 7, Serotonin receptor 7
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of HTR7

  • At this stage in the migraine process, activation of specific subtypes of 5-HT1 receptors has proven clinically effective in relieving migraine pain [1].
  • Blocking 5-HT1A receptors attenuated bradycardias evoked by stimulating baroreceptor and cardiopulmonary afferents but not arterial chemoreceptors, whereas antagonizing 5-HT7 receptors markedly attenuated all these reflex bradycardias [2].
  • Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells [3].
  • To this end, pulmonary ventilation (V(E)) of rats was measured before and after intra-AVPO microinjection of methysergide (a 5-HT1 and 5-HT2 receptor antagonist), WAY-100635 (a 5-HT1A receptor antagonist) and SB-269970 (a 5-HT7 receptor antagonist), followed by 60 min of hypoxia exposure (7% O2) [4].
  • Recently, we have demonstrated that potassium channels containing G-protein-activated potassium channel 2 (GIRK2) subunits play a significant role in hypothermia induced by several neurotransmitter receptor agonists, including the serotonin (5-HT)1A/5-HT7 receptor agonist 8-OH-DPAT [R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin] [5].

Psychiatry related information on HTR7


High impact information on HTR7

  • A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms [11].
  • 5-HT7 mRNA is expressed discretely throughout the CNS, predominantly in the thalamus and hypothalamus [11].
  • Indeed, 5-HT7 receptors have been implicated in the pathophysiology of several disorders; they play a role in smooth muscle relaxation within the vasculature and in the gastrointestinal tract [12].
  • In doing so, they advocate that the so-called '5-HT1-like' receptors, having been shown to be a heterogeneous population of 5-HT1B, 5-HT1D and 5-HT7 receptors, are now redundant [13].
  • In recent years, cloning has revealed the existence of no less than 14 mammalian 5-HT receptors, as well as evidence that isoforms of the 5-HT4 and 5-HT7 receptors are generated by alternative splicing [14].

Chemical compound and disease context of HTR7


Biological context of HTR7


Anatomical context of HTR7


Associations of HTR7 with chemical compounds

  • A novel serotonin receptor designated 5HT7 (genetic locus HTR7) was cloned in 1993 [6].
  • Evaluation of serotonin (5HT), melatonin (MT), and melatonin-related receptors (MRR) showed expression of the isoforms 5HT2B, 5HT7, and MT1 genes in almost all the tested samples [20].
  • This study investigated the effects of the T-->C 267 polymorphism in the 5HT6 receptor gene and two rare Pro279Leu and Thr92Lys substitutions in the 5HT7 receptor gene on risperidone efficacy after rigorous control for nongenetic confounders [21].
  • Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase [22].
  • In contrast, 5-carboxamidotryptamine induced strong increases (> or = 400%, P < .005) in basal cyclic AMP levels that were abolished by mesulergine, a nonselective 5-HT7 receptor antagonist [19].

Regulatory relationships of HTR7

  • Furthermore, IL-6 synthesis was induced by the 5-HT7 receptor agonist carboxamidotryptamin [3].
  • Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells [23].

Other interactions of HTR7


Analytical, diagnostic and therapeutic context of HTR7

  • In the present study, we tested the ability of MDMA and fenfluramine treatment to alter the ability of the circadian clock to reset in response to an agonist of the 5-HT1A and 5-HT7 receptor subtypes soon after treatment with the drugs, and then again at 20 weeks [26].
  • The selective serotonin reuptake inhibitor citalopram, a widely used antidepressant, decreased immobility in both 5-HT7+/+ and 5-HT7-/- mice in the tail suspension test, suggesting that it utilizes an independent mechanism [10].
  • RESULTS: RT-PCR revealed the presence of a 5-HT7 receptor mRNA in CEPI-17-CL4 cells [27].
  • Western blot analysis revealed the presence of immunoreactive bands corresponding to the human 5-HT7 receptor in extracts of MC-3 cells [28].
  • Sequence analysis revealed the presence of a single message that matched the sequence of the cloned human 5-HT7 receptor [29].


  1. The biology of serotonin receptors: focus on migraine pathophysiology and treatment. Hamel, E. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1999) [Pubmed]
  2. Vagal control of the heart: central serotonergic (5-HT) mechanisms. Jordan, D. Exp. Physiol. (2005) [Pubmed]
  3. Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells. Lieb, K., Biersack, L., Waschbisch, A., Orlikowski, S., Akundi, R.S., Candelario-Jalil, E., Hüll, M., Fiebich, B.L. J. Neurochem. (2005) [Pubmed]
  4. Serotoninergic receptors in the anteroventral preoptic region modulate the hypoxic ventilatory response. Gargaglioni, L.H., Bícego, K.C., Nucci, T.B., Branco, L.G. Respiratory physiology & neurobiology. (2006) [Pubmed]
  5. Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome. Stasko, M.R., Scott-McKean, J.J., Costa, A.C. Neuroreport (2006) [Pubmed]
  6. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome. Gelernter, J., Rao, P.A., Pauls, D.L., Hamblin, M.W., Sibley, D.R., Kidd, K.K. Genomics (1995) [Pubmed]
  7. Physical mapping of the serotonin 5-HT(7) receptor gene (HTR7) to chromosome 10 and pseudogene (HTR7P) to chromosome 12, and testing of linkage disequilibrium between HTR7 and autistic disorder. Lassig, J.P., Vachirasomtoon, K., Hartzell, K., Leventhal, M., Courchesne, E., Courchesne, R., Lord, C., Leventhal, B.L., Cook, E.H. Am. J. Med. Genet. (1999) [Pubmed]
  8. The human serotonin 7 (5-HT7) receptor gene: genomic organization and systematic mutation screening in schizophrenia and bipolar affective disorder. Erdmann, J., Nöthen, M.M., Shimron-Abarbanell, D., Rietschel, M., Albus, M., Borrmann, M., Maier, W., Franzek, E., Körner, J., Weigelt, B., Fimmers, R., Propping, P. Mol. Psychiatry (1996) [Pubmed]
  9. Phase-shifting effect of 8-OH-DPAT, a 5-HT1A/5-HT7 receptor agonist, on locomotor activity in golden hamster in constant darkness. Cutrera, R.A., Saboureau, M., Pévet, P. Neurosci. Lett. (1996) [Pubmed]
  10. 5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern. Hedlund, P.B., Huitron-Resendiz, S., Henriksen, S.J., Sutcliffe, J.G. Biol. Psychiatry (2005) [Pubmed]
  11. A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Lovenberg, T.W., Baron, B.M., de Lecea, L., Miller, J.D., Prosser, R.A., Rea, M.A., Foye, P.E., Racke, M., Slone, A.L., Siegel, B.W. Neuron (1993) [Pubmed]
  12. 5-HT7 receptors: current knowledge and future prospects. Vanhoenacker, P., Haegeman, G., Leysen, J.E. Trends Pharmacol. Sci. (2000) [Pubmed]
  13. 5-HT1-like receptors: a time to bid goodbye. Saxena, P.R., De Vries, P., Villalón, C.M. Trends Pharmacol. Sci. (1998) [Pubmed]
  14. New players in the 5-HT receptor field: genes and knockouts. Lucas, J.J., Hen, R. Trends Pharmacol. Sci. (1995) [Pubmed]
  15. Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. Masellis, M., Basile, V.S., Meltzer, H.Y., Lieberman, J.A., Sevy, S., Goldman, D.A., Hamblin, M.W., Macciardi, F.M., Kennedy, J.L. Schizophr. Res. (2001) [Pubmed]
  16. Serotonin receptor subtype mRNA expression in human ocular tissues, determined by RT-PCR. Sharif, N.A., Senchyna, M. Mol. Vis. (2006) [Pubmed]
  17. Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide. Thomas, E.A., Carson, M.J., Neal, M.J., Sutcliffe, J.G. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  18. Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor. Baker, L.P., Nielsen, M.D., Impey, S., Metcalf, M.A., Poser, S.W., Chan, G., Obrietan, K., Hamblin, M.W., Storm, D.R. J. Biol. Chem. (1998) [Pubmed]
  19. Multiple microvascular and astroglial 5-hydroxytryptamine receptor subtypes in human brain: molecular and pharmacologic characterization. Cohen, Z., Bouchelet, I., Olivier, A., Villemure, J.G., Ball, R., Stanimirovic, D.B., Hamel, E. J. Cereb. Blood Flow Metab. (1999) [Pubmed]
  20. Functional activity of serotoninergic and melatoninergic systems expressed in the skin. Slominski, A., Pisarchik, A., Zbytek, B., Tobin, D.J., Kauser, S., Wortsman, J. J. Cell. Physiol. (2003) [Pubmed]
  21. Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders. Lane, H.Y., Lin, C.C., Huang, C.H., Chang, Y.C., Hsu, S.K., Chang, W.H. Schizophr. Res. (2004) [Pubmed]
  22. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. Bard, J.A., Zgombick, J., Adham, N., Vaysse, P., Branchek, T.A., Weinshank, R.L. J. Biol. Chem. (1993) [Pubmed]
  23. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Zhukovskaya, N.L., Neumaier, J.F. Neurosci. Lett. (2000) [Pubmed]
  24. Interaction of the anxiogenic agent, RS-30199, with 5-HT1A receptors: modulation of sexual activity in the male rat. Spedding, M., Newman-Tancredi, A., Millan, M.J., Dacquet, C., Michel, A.N., Jacoby, E., Vickery, B., Tallentire, D. Neuropharmacology (1998) [Pubmed]
  25. Autosomal linkage analysis for the level of response to alcohol. Schuckit, M.A., Wilhelmsen, K., Smith, T.L., Feiler, H.S., Lind, P., Lange, L.A., Kalmijn, J. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
  26. MDMA and fenfluramine alter the response of the circadian clock to a serotonin agonist in vitro. Biello, S.M., Dafters, R.I. Brain Res. (2001) [Pubmed]
  27. Pharmacological characterization of a serotonin receptor (5-HT7) stimulating cAMP production in human corneal epithelial cells. Crider, J.Y., Williams, G.W., Drace, C.D., Katoli, P., Senchyna, M., Sharif, N.A. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  28. Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells. Mahé, C., Loetscher, E., Dev, K.K., Bobirnac, I., Otten, U., Schoeffter, P. Neuropharmacology (2005) [Pubmed]
  29. 5-HT7 receptor mRNA expression in human trigeminal ganglia. Terrón, J.A., Bouchelet, I., Hamel, E. Neurosci. Lett. (2001) [Pubmed]
WikiGenes - Universities