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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Hepatic sinusoidal responses to intraportal injections of phenylephrine and isoprenaline in the rat.

1. Specific alpha- and beta-adrenoreceptor agonists, phenylephrine and isoprenaline, were injected intraportally into the intact rat liver under direct microscopic observation by an in vivo transillumination technique. 2. The diameter of a hepatic sinusoid and the intra-sinusoidal erythrocyte velocity were quantitatively measured, and the sinusoidal volume flow was calculated from these two parameters. 3. Results show that phenylephrine causes a sinusoidal constriction and an increased sinusoidal blood flow, whereas isoprenaline causes the opposite effects on the sinusoids. 4. All the sinusoidal responses to phenylephrine and isoprenaline were dose-dependent and were possibly related to the direct effect of these drugs on the sinusoids.[1]

References

  1. Hepatic sinusoidal responses to intraportal injections of phenylephrine and isoprenaline in the rat. Koo, A., Liang, I.Y., Cheng, K.K. Clin. Exp. Pharmacol. Physiol. (1976) [Pubmed]
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