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Chemical Compound Review

Euspiran     4-[1-hydroxy-2-(propan-2...

Synonyms: Isadrine, Novodrin, Isadrin, Isuprel, Norisodrine, ...
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Disease relevance of Isopropyl noradrenaline

  • We assessed beta-blockade by measuring the reduction in tachycardia produced by boluses of isoproterenol and treadmill exercise in 14 normal subjects during treatment with placebo and with 150, 225, and 300 mg of propafenone every eight hours for five days each [1].
  • We conclude that an isoproterenol infusion administered in conjunction with the upright-tilt test may be useful for identifying susceptibility to neurally mediated recurrent syncope [2].
  • We used the "upright-tilt test" (duration, less than or equal to 10 minutes) with or without an infusion of exogenous catecholamine (isoproterenol [1 to 5 micrograms per minute], given intravenously) to elicit bradycardia, hypotension, or both in 24 patients with recurrent syncope and in 18 control subjects [2].
  • The tilt test alone (i.e., without isoproterenol) induced symptomatic bradycardia or hypotension in 1 of the 9 patients with positive electrophysiologic tests (11 percent), 4 of the 15 patients with negative electrophysiologic tests (27 percent), and none of the controls [2].
  • Our findings suggest that the mechanisms responsible for blunted vasodilatation in response to the administration of isoproterenol may contribute to enhanced vascular reactivity in blacks and may play a part in the pathogenesis of hypertension in blacks [3].

Psychiatry related information on Isopropyl noradrenaline


High impact information on Isopropyl noradrenaline


Chemical compound and disease context of Isopropyl noradrenaline


Biological context of Isopropyl noradrenaline


Anatomical context of Isopropyl noradrenaline

  • In seven patients with cough, studies revealed a more severe obstructive pattern that appeared to be the result of increased large-airway resistance, and the patients' response to isoproterenol indicated that contraction of bronchial smooth muscle may have been principally responsible [22].
  • Increasing pulmonary blood flow by isoproterenol infusion or decreasing pulmonary blood flow by partial bypass of the right side of the heart minimally altered pulmonary-artery pressure [23].
  • An isoprenaline activated sodium-dependent inward current in ventricular myocytes [24].
  • We show here that stimulation of alpha-receptors in renal membranes causes a specific decrease in the affinity of the agonist compound isoprenaline for beta-receptors in the same membranes [25].
  • The response of these subpopulations of lymphocytes to isoproterenol is the inverse of the histamine response [26].

Associations of Isopropyl noradrenaline with other chemical compounds


Gene context of Isopropyl noradrenaline

  • In dog fat cells NPY and PYY inhibited adenosine deaminase-, isoproterenol- and forskolin-induced lipolysis [31].
  • Beta l-AR -/- mice that do survive to adulthood appear normal, but lack the chronotropic and inotropic responses seen in wild-type mice when beta-AR agonists such as isoproterenol are administered [32].
  • ERK1/2 activation by dual efficacy ligands was not affected by ADP-ribosylation of Galphai and could be observed in S49-cyc- cells lacking Galphas indicating that, unlike the conventional agonist isoproterenol, these drugs induce ERK1/2 activation in a Gs/i-independent manner [33].
  • Compounds that increase cAMP and activate protein kinase A (PKA)--prostaglandin E2, isoproterenol, cholera toxin, and forskolin--were found to inhibit the PDGF-BB-induced activation of MAPKK and MAPK [34].
  • The beta-adrenergic agonist isoproterenol was without effect in the absence of insulin but markedly reduced the increases in ERK1 and ERK2 activities produced by the hormone [35].

Analytical, diagnostic and therapeutic context of Isopropyl noradrenaline

  • We used venous-occlusion plethysmography to measure the responses of blood flow in the forearm to the intraarterial administration of isoproterenol (10 to 400 ng per minute) in 9 normotensive black men (mean [+/- SD] age, 31.3 +/- 8.0 years) and 13 normotensive white men (mean age, 32.9 +/- 5.6 years) [3].
  • We have now examined the effect of isoprenaline and protein kinase A on Ca2+-dependent K+-channels in isolated smooth muscle cells of rabbit trachea, using the patch-clamp technique [36].
  • INTERVENTIONS--Each subject completed a symptom questionnaire and underwent a three-stage upright tilt-table test (stage 1, 45 minutes at 70 degrees tilt; stage 2, 15 minutes at 70 degrees tilt with 1 to 2 micrograms/min of isoproterenol; and stage 3, 10 minutes at 70 degrees with 3 to 4 micrograms/min of isoproterenol) [37].
  • (b) 7 patients had VT suggestive of catecholamine-sensitive automaticity as VT could not be initiated with programmed electrical stimulation but could be provoked by isoproterenol infusion [38].
  • CREB-like DNA-binding activity was decreased after Iso treatment but this decrease was prevented after treatment with Dex [39].


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  13. Human fat cell lipolysis is primarily regulated by inhibitory modulators acting through distinct mechanisms. Kather, H., Bieger, W., Michel, G., Aktories, K., Jakobs, K.H. J. Clin. Invest. (1985) [Pubmed]
  14. Effects of pressure overload, left ventricular hypertrophy on beta-adrenergic receptors, and responsiveness to catecholamines. Vatner, D.E., Homcy, C.J., Sit, S.P., Manders, W.T., Vatner, S.F. J. Clin. Invest. (1984) [Pubmed]
  15. Inhibition of lipolysis by adenosine is potentiated with age. Hoffman, B.B., Chang, H., Farahbakhsh, Z., Reaven, G. J. Clin. Invest. (1984) [Pubmed]
  16. Mechanism of rhinovirus-induced changes in airway smooth muscle responsiveness. Hakonarson, H., Maskeri, N., Carter, C., Hodinka, R.L., Campbell, D., Grunstein, M.M. J. Clin. Invest. (1998) [Pubmed]
  17. Alterations in leukocyte beta-receptor affinity with aging. A potential explanation for altered beta-adrenergic sensitivity in the elderly. Feldman, R.D., Limbird, L.E., Nadeau, J., Robertson, D., Wood, A.J. N. Engl. J. Med. (1984) [Pubmed]
  18. Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Milano, C.A., Allen, L.F., Rockman, H.A., Dolber, P.C., McMinn, T.R., Chien, K.R., Johnson, T.D., Bond, R.A., Lefkowitz, R.J. Science (1994) [Pubmed]
  19. Regulation of muscle differentiation: stimulation of myoblast fusion in vitro by catecholamines. Curtis, D.H., Zalin, R.J. Science (1981) [Pubmed]
  20. Lipolytic catecholamine resistance due to decreased beta 2-adrenoceptor expression in fat cells. Lönnqvist, F., Wahrenberg, H., Hellström, L., Reynisdottir, S., Arner, P. J. Clin. Invest. (1992) [Pubmed]
  21. beta-Adrenergic modulation of the inwardly rectifying potassium channel in isolated human ventricular myocytes. Alteration in channel response to beta-adrenergic stimulation in failing human hearts. Koumi, S., Backer, C.L., Arentzen, C.E., Sato, R. J. Clin. Invest. (1995) [Pubmed]
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  30. Normalization of depressed heart function in rats by ribose. Zimmer, H.G. Science (1983) [Pubmed]
  31. Neuropeptide Y and peptide YY inhibit lipolysis in human and dog fat cells through a pertussis toxin-sensitive G protein. Valet, P., Berlan, M., Beauville, M., Crampes, F., Montastruc, J.L., Lafontan, M. J. Clin. Invest. (1990) [Pubmed]
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  33. Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Azzi, M., Charest, P.G., Angers, S., Rousseau, G., Kohout, T., Bouvier, M., Piñeyro, G. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  34. Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. Graves, L.M., Bornfeldt, K.E., Raines, E.W., Potts, B.C., Macdonald, S.G., Ross, R., Krebs, E.G. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
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