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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Riboregulation in Escherichia coli: DsrA RNA acts by RNA:RNA interactions at multiple loci.

DsrA is an 87-nt untranslated RNA that regulates both the global transcriptional silencer and nucleoid protein H-NS and the stationary phase and stress response sigma factor RpoS (sigmas). We demonstrate that DsrA acts via specific RNA:RNA base pairing interactions at the hns locus to antagonize H-NS translation. We also give evidence that supports a role for RNA:RNA interactions at the rpoS locus to enhance RpoS translation. Negative regulation of hns by DsrA is achieved by the RNA:RNA interaction blocking translation of hns RNA. In contrast, results suggest that positive regulation of rpoS by DsrA occurs by formation of an RNA structure that activates a cis-acting translational operator. Sequences within DsrA complementary to three additional genes, argR, ilvIH, and rbsD, suggest that DsrA is a riboregulator of gene expression that acts coordinately via RNA:RNA interactions at multiple loci.[1]


  1. Riboregulation in Escherichia coli: DsrA RNA acts by RNA:RNA interactions at multiple loci. Lease, R.A., Cusick, M.E., Belfort, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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