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Gene Review

rpoS  -  RNA polymerase sigma factor RpoS

Escherichia coli UTI89

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Disease relevance of rpoS


High impact information on rpoS


Chemical compound and disease context of rpoS

  • When tetracycline was present, tetA(C) reduced acid tolerance, suppressed rpoS expression, and increased the concentration of total soluble proteins in stationary-phase Escherichia coli [8].

Biological context of rpoS

  • There were no major differences in the DNA sequences in the rpoS coding regions among the tested strains [1].
  • During the transition from mildly acidic growth conditions (pH 5.5) to alkaline stress (pH 10.2), cell survival was dependent on rpoS functionality [1].
  • The changes in the gene expressions, enzyme activities and intracellular metabolite concentrations of the rpoS mutant are discussed in details with reference to the major metabolic pathways of E. coli [9].
  • Silencing of the Escherichia coli bgl operon is mediated by histone-like protein H-NS and affected by other pleiotropic regulators, including sigma factor RpoS [10].
  • Under starvation conditions, a variety of stationary phase genes are up-regulated under the control of the stationary phase sigma factor RpoS including at least two peroxidases and a protective DNA binding protein Dps [11].

Associations of rpoS with chemical compounds

  • The induction of mdtEF by GlcNAc is not mediated by the evgSA, ydeO, gadX, and rpoS signaling pathways that have been known to regulate mdtEF expression [12].
  • Expression of the first AR system (designated the oxidative or glucose-repressed AR system) was previously shown to require the alternative sigma factor RpoS [13].
  • The alternate sigma factor RpoS was shown to be required for oxidative acid resistance but was only partially involved with the arginine- and glutamate-dependent acid resistance systems [14].


  1. Functional heterogeneity of RpoS in stress tolerance of enterohemorrhagic Escherichia coli strains. Bhagwat, A.A., Tan, J., Sharma, M., Kothary, M., Low, S., Tall, B.D., Bhagwat, M. Appl. Environ. Microbiol. (2006) [Pubmed]
  2. The PhoP/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica. Tu, X., Latifi, T., Bougdour, A., Gottesman, S., Groisman, E.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary-phase sigma factor RpoS. Latifi, A., Foglino, M., Tanaka, K., Williams, P., Lazdunski, A. Mol. Microbiol. (1996) [Pubmed]
  4. The Pseudomonas aeruginosa RpoS regulon and its relationship to quorum sensing. Schuster, M., Hawkins, A.C., Harwood, C.S., Greenberg, E.P. Mol. Microbiol. (2004) [Pubmed]
  5. The response regulator expM is essential for the virulence of Erwinia carotovora subsp. carotovora and acts negatively on the sigma factor RpoS (sigma s). Andersson, R.A., Palva, E.T., Pirhonen, M. Mol. Plant Microbe Interact. (1999) [Pubmed]
  6. A microarray-based antibiotic screen identifies a regulatory role for supercoiling in the osmotic stress response of Escherichia coli. Cheung, K.J., Badarinarayana, V., Selinger, D.W., Janse, D., Church, G.M. Genome Res. (2003) [Pubmed]
  7. Artificial regulation of ospC expression in Borrelia burgdorferi. Gilbert, M.A., Morton, E.A., Bundle, S.F., Samuels, D.S. Mol. Microbiol. (2007) [Pubmed]
  8. Reduction of acid tolerance by tetracycline in Escherichia coli expressing tetA(C) is reversed by cations. Hung, K.F., Byrd, J.J., Bose, J.L., Kaspar, C.W. Appl. Environ. Microbiol. (2006) [Pubmed]
  9. Effect of rpoS gene knockout on the metabolism of Escherichia coli during exponential growth phase and early stationary phase based on gene expressions, enzyme activities and intracellular metabolite concentrations. Rahman, M., Hasan, M.R., Oba, T., Shimizu, K. Biotechnol. Bioeng. (2006) [Pubmed]
  10. Silencing of the Escherichia coli bgl operon by RpoS requires Crl. Schnetz, K. Microbiology (Reading, Engl.) (2002) [Pubmed]
  11. Effect of endogenous carotenoids and defective RpoS sigma factor on spontaneous mutation under starvation conditions in Escherichia coli: evidence for the possible involvement of singlet oxygen. Bridges, B.A., Timms, A. Mutat. Res. (1998) [Pubmed]
  12. N-acetyl-d-glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichia coli. Hirakawa, H., Inazumi, Y., Senda, Y., Kobayashi, A., Hirata, T., Nishino, K., Yamaguchi, A. J. Bacteriol. (2006) [Pubmed]
  13. Control of acid resistance in Escherichia coli. Castanie-Cornet, M.P., Penfound, T.A., Smith, D., Elliott, J.F., Foster, J.W. J. Bacteriol. (1999) [Pubmed]
  14. Mechanisms of acid resistance in enterohemorrhagic Escherichia coli. Lin, J., Smith, M.P., Chapin, K.C., Baik, H.S., Bennett, G.N., Foster, J.W. Appl. Environ. Microbiol. (1996) [Pubmed]
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