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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Role of the C terminus of FtsK in Escherichia coli chromosome segregation.

FtsK is essential for Escherichia coli cell division. We report that cells lacking the C terminus of FtsK are defective in chromosome segregation as well as septation, often exhibiting asymmetrically positioned nucleoids and large anucleate regions. Combining the corresponding truncated ftsK gene with a mukB null mutation resulted in a synthetic lethal phenotype. When the truncated ftsK was combined with a minCDE deletion, chains of minicells were generated, many of which contained DNA. These results suggest that the C terminus of FtsK has an important role in chromosome partitioning.[1]


  1. Role of the C terminus of FtsK in Escherichia coli chromosome segregation. Yu, X.C., Weihe, E.K., Margolin, W. J. Bacteriol. (1998) [Pubmed]
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