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Gene Review

mukB  -  chromosome condensin MukBEF, ATPase and...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0915, JW0907
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Disease relevance of mukB


High impact information on mukB

  • mukB mutants of Escherichia coli are defective in the correct partitioning of replicated chromosomes [3].
  • Based on the nucleotide sequence of the mukB gene, the MukB protein of 177 kDa was predicted to be a filamentous protein with globular domains at the ends, and also having DNA binding and nucleotide binding abilities [3].
  • The most surprising result of this study was revealed upon further examination of FtsZ ring positioning in anucleate cells generated by the parC and mukB mutants: many of these cells, despite having no chromosome, possessed FtsZ rings at their midpoints [4].
  • However, none of them could suppress both phenotypes in a mukB null mutation [5].
  • We found that NO was mostly normal in cells with inactivated DNA gyrase or in mukB-null mutants lacking topA, although some suppression of NO was evident in the latter case [6].

Biological context of mukB


Associations of mukB with chemical compounds


Other interactions of mukB


  1. Complex formation of MukB, MukE and MukF proteins involved in chromosome partitioning in Escherichia coli. Yamazoe, M., Onogi, T., Sunako, Y., Niki, H., Yamanaka, K., Ichimura, T., Hiraga, S. EMBO J. (1999) [Pubmed]
  2. Mutants suppressing novobiocin hypersensitivity of a mukB null mutation. Adachi, S., Hiraga, S. J. Bacteriol. (2003) [Pubmed]
  3. E.coli MukB protein involved in chromosome partition forms a homodimer with a rod-and-hinge structure having DNA binding and ATP/GTP binding activities. Niki, H., Imamura, R., Kitaoka, M., Yamanaka, K., Ogura, T., Hiraga, S. EMBO J. (1992) [Pubmed]
  4. Assembly of the FtsZ ring at the central division site in the absence of the chromosome. Sun, Q., Yu, X.C., Margolin, W. Mol. Microbiol. (1998) [Pubmed]
  5. Cloning, sequencing, and characterization of multicopy suppressors of a mukB mutation in Escherichia coli. Yamanaka, K., Mitani, T., Ogura, T., Niki, H., Hiraga, S. Mol. Microbiol. (1994) [Pubmed]
  6. Effects of perturbing nucleoid structure on nucleoid occlusion-mediated toporegulation of FtsZ ring assembly. Sun, Q., Margolin, W. J. Bacteriol. (2004) [Pubmed]
  7. New killing system controlled by two genes located immediately upstream of the mukB gene in Escherichia coli. Feng, J., Yamanaka, K., Niki, H., Ogura, T., Hiraga, S. Mol. Gen. Genet. (1994) [Pubmed]
  8. Identification of two new genes, mukE and mukF, involved in chromosome partitioning in Escherichia coli. Yamanaka, K., Ogura, T., Niki, H., Hiraga, S. Mol. Gen. Genet. (1996) [Pubmed]
  9. Partition of P1 plasmids in Escherichia coli mukB chromosomal partition mutants. Funnell, B.E., Gagnier, L. J. Bacteriol. (1995) [Pubmed]
  10. Two mutant alleles of mukB, a gene essential for chromosome partition in Escherichia coli. Yamanaka, K., Mitani, T., Feng, J., Ogura, T., Niki, H., Hiraga, S. FEMS Microbiol. Lett. (1994) [Pubmed]
  11. Role of the C terminus of FtsK in Escherichia coli chromosome segregation. Yu, X.C., Weihe, E.K., Margolin, W. J. Bacteriol. (1998) [Pubmed]
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