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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets.

We report here that the expression of virtually all proposed c-Myc target genes is unchanged in cells containing a homozygous null deletion of c-myc. Two noteworthy exceptions are the gene cad, which has reduced log phase expression and serum induction in c-myc null cells, and the growth arrest gene gadd45, which is derepressed by c-myc knockout. Thus, cad and gadd45 are the only proposed targets of c-Myc that may contribute to the dramatic slow growth phenotype of c-myc null cells. Our results demonstrate that a loss-of-function approach is critical for the evaluation of potential c-Myc target genes.[1]


  1. c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets. Bush, A., Mateyak, M., Dugan, K., Obaya, A., Adachi, S., Sedivy, J., Cole, M. Genes Dev. (1998) [Pubmed]
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