Gene Review:
Myc - myelocytomatosis oncogene
Rattus norvegicus
Synonyms:
Myc proto-oncogene protein, Proto-oncogene c-Myc, RNCMYC, Transcription factor p64, c-myc, ...
- The Adrenomedullin gene is a target for negative regulation by the Myc transcription complex. Wang, X., Peters, M.A., Utama, F.E., Wang, Y., Taparowsky, E.J. Mol. Endocrinol. (1999)
- c-Myc does not require max for transcriptional activity in PC-12 cells. Ribon, V., Leff, T., Saltiel, A.R. Mol. Cell. Neurosci. (1994)
- Kinetics of myc-max-mad gene expression during hepatocyte proliferation in vivo: Differential regulation of mad family and stress-mediated induction of c-myc. Mauleon, I., Lombard, M.N., Muñoz-Alonso, M.J., Cañelles, M., Leon, J. Mol. Carcinog. (2004)
- Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation. Kaneto, H., Sharma, A., Suzuma, K., Laybutt, D.R., Xu, G., Bonner-Weir, S., Weir, G.C. J. Biol. Chem. (2002)
- Kainic acid-induced apoptosis in rat striatum is associated with nuclear factor-kappaB activation. Nakai, M., Qin, Z.H., Chen, J.F., Wang, Y., Chase, T.N. J. Neurochem. (2000)
- Induction of apoptosis in fibroblasts by c-myc protein. Evan, G.I., Wyllie, A.H., Gilbert, C.S., Littlewood, T.D., Land, H., Brooks, M., Waters, C.M., Penn, L.Z., Hancock, D.C. Cell (1992)
- Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis. Pascale, R.M., Simile, M.M., De Miglio, M.R., Muroni, M.R., Calvisi, D.F., Asara, G., Casabona, D., Frau, M., Seddaiu, M.A., Feo, F. Hepatology (2002)
- Mithramycin inhibits myointimal proliferation after balloon injury of the rat carotid artery in vivo. Chen, S.J., Chen, Y.F., Miller, D.M., Li, H., Oparil, S. Circulation (1994)
- c-myc in vasculoproliferative disease. Edelman, E.R., Simons, M., Sirois, M.G., Rosenberg, R.D. Circ. Res. (1995)
- Differences in the steady-state levels of c-fos, c-jun and c-myc messenger RNA during mitogen-induced liver growth and compensatory regeneration. Coni, P., Simbula, G., de Prati, A.C., Menegazzi, M., Suzuki, H., Sarma, D.S., Ledda-Columbano, G.M., Columbano, A. Hepatology (1993)
- Increased expression of nucleoside diphosphate kinase/nm23 and c-Ha-ras mRNA is associated with spontaneous lung metastasis in rat-transplantable osteosarcomas. Honoki, K., Tsutsumi, M., Miyauchi, Y., Mii, Y., Tsujiuchi, T., Morishita, T., Miura, S., Aoki, M., Kobayashi, E., Tamai, S. Cancer Res. (1993)
- Myc influences global chromatin structure. Knoepfler, P.S., Zhang, X.Y., Cheng, P.F., Gafken, P.R., McMahon, S.B., Eisenman, R.N. EMBO J. (2006)
- Myc drives apoptosis in PC12 cells in the absence of Max. Wert, M., Kennedy, S., Palfrey, H.C., Hay, N. Oncogene (2001)
- Induction of max by adrenomedullin and calcitonin gene-related peptide antagonizes endothelial apoptosis. Shichiri, M., Kato, H., Doi, M., Marumo, F., Hirata, Y. Mol. Endocrinol. (1999)
- Repression of Myc-Ras cotransformation by Mad is mediated by multiple protein-protein interactions. Koskinen, P.J., Ayer, D.E., Eisenman, R.N. Cell Growth Differ. (1995)
- Expression of c-Fos and c-Myc and deposition of beta-APP in neurons in the adult rat brain as a result of exposure to short-lasting impulse noise. Säljö, A., Bao, F., Shi, J., Hamberger, A., Hansson, H.A., Haglid, K.G. J. Neurotrauma (2002)
- Rat carotid arteriotomy: c-myc is involved in negative remodelling and apoptosis. De Feo, M., Forte, A., Onorati, F., Renzulli, A., Cipollaro, M., Cotrufo, M., Rossi, F., Cascino, A. Journal of cardiovascular medicine (Hagerstown, Md.) (2006)
- Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region. Liu, L., Guo, X., Rao, J.N., Zou, T., Marasa, B.S., Chen, J., Greenspon, J., Casero, R.A., Wang, J.Y. Biochem. J. (2006)
- A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism. Nikiforov, M.A., Chandriani, S., O'Connell, B., Petrenko, O., Kotenko, I., Beavis, A., Sedivy, J.M., Cole, M.D. Mol. Cell. Biol. (2002)
- Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Soucie, E.L., Annis, M.G., Sedivy, J., Filmus, J., Leber, B., Andrews, D.W., Penn, L.Z. Mol. Cell. Biol. (2001)
- Alternative forms of Max as enhancers or suppressors of Myc-ras cotransformation. Mäkelä, T.P., Koskinen, P.J., Västrik, I., Alitalo, K. Science (1992)
- Differential regulation of AP-1 and novel TRE-specific DNA-binding complexes during differentiation of oligodendrocyte-type-2-astrocyte (O-2A) progenitor cells. Barnett, S.C., Rosario, M., Doyle, A., Kilbey, A., Lovatt, A., Gillespie, D.A. Development (1995)
- Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration. Rodríguez, J.L., Sandoval, J., Serviddio, G., Sastre, J., Morante, M., Perrelli, M.G., Martínez-Chantar, M.L., Viña, J., Viña, J.R., Mato, J.M., Avila, M.A., Franco, L., López-Rodas, G., Torres, L. Biochem. J. (2006)
- Promoter-binding and repression of PDGFRB by c-Myc are separable activities. Mao, D.Y., Barsyte-Lovejoy, D., Ho, C.S., Watson, J.D., Stojanova, A., Penn, L.Z. Nucleic Acids Res. (2004)
- Inhibitory effect of antisense oligodeoxynucleotide to p44/p42 MAPK on angiotensin II-induced hypertrophic response in cultured neonatal rat cardiac myocyte. Zhang, S.Q., Ding, B., Guo, Z.G., Li, Y.X. Acta Pharmacol. Sin. (2004)
- Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2. Wagner, A.J., Small, M.B., Hay, N. Mol. Cell. Biol. (1993)
- Activation of c-Myc uncouples DNA replication from activation of G1-cyclin-dependent kinases. Pusch, O., Bernaschek, G., Eilers, M., Hengstschläger, M. Oncogene (1997)
- c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms. Sakamuro, D., Eviner, V., Elliott, K.J., Showe, L., White, E., Prendergast, G.C. Oncogene (1995)
- Implication of Bcl-2 family genes in basal and D-amphetamine-induced apoptosis in preneoplastic and neoplastic rat liver lesions. De Miglio, M.R., Muroni, M.R., Simile, M.M., Calvisi, D.F., Tolu, P., Deiana, L., Carru, A., Bonelli, G., Feo, F., Pascale, R.M. Hepatology (2000)
- Expressions of c-myc and insulin-like growth factor-1 mRNA in the liver of growing rats vary reciprocally in response to changes in dietary protein. Kanamoto, R., Yokota, T., Hayashi, S.I. J. Nutr. (1994)
- A modest reduction in c-myc expression has minimal effects on cell growth and apoptosis but dramatically reduces susceptibility to Ras and Raf transformation. Bazarov, A.V., Adachi, S., Li, S.F., Mateyak, M.K., Wei, S., Sedivy, J.M. Cancer Res. (2001)
- Targeting c-Myc-activated genes with a correlation method: detection of global changes in large gene expression network dynamics. Remondini, D., O'Connell, B., Intrator, N., Sedivy, J.M., Neretti, N., Castellani, G.C., Cooper, L.N. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Direct activation of RNA polymerase III transcription by c-Myc. Gomez-Roman, N., Grandori, C., Eisenman, R.N., White, R.J. Nature (2003)
- Nucleolar localization of hepatic c-Myc: a potential mechanism for c-Myc regulation. Sanders, J.A., Gruppuso, P.A. Biochim. Biophys. Acta (2005)