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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist.

The synthesis and SAR of benzylamine side chain analogs of the NK-1 receptor antagonist CP-99,994 are described. The 5-trifluoromethoxy analog, CP-122,721, shows superior in vivo blockade of NK-1 receptor mediated responses.[1]

References

  1. Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist. Rosen, T.J., Coffman, K.J., McLean, S., Crawford, R.T., Bryce, D.K., Gohda, Y., Tsuchiya, M., Nagahisa, A., Nakane, M., Lowe, J.A. Bioorg. Med. Chem. Lett. (1998) [Pubmed]
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