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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Carbapenem activities against Pseudomonas aeruginosa: respective contributions of OprD and efflux systems.

While meropenem MICs were strongly influenced by the presence or absence of the MexAB-OprM efflux pump in both OprD-proficient and -deficient strain backgrounds, MICs of imipenem and of ER-35786 remained unchanged, demonstrating that meropenem is a substrate of MexAB-OprM but not imipenem and ER-35786. In vitro, all three carbapenems selected loss of OprD as a first mechanism of resistance. However, in an OprD-deficient background, meropenem was able to select MexAB-OprM overproducers as a secondary resistance mechanism, while ER-35786 selected a mutant cross-resistant to sparfloxacin and cefpirome.[1]

References

  1. Carbapenem activities against Pseudomonas aeruginosa: respective contributions of OprD and efflux systems. Köhler, T., Michea-Hamzehpour, M., Epp, S.F., Pechere, J.C. Antimicrob. Agents Chemother. (1999) [Pubmed]
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