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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Evidence for protein splicing in the endoplasmic reticulum-Golgi intermediate compartment.

We present evidence that the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is a site for protein splicing of cathepsin C: (i) maturation of the enzyme in COS 7 cells is a two-step process starting within the ERGIC, and (ii) the intermediately processed polypeptide retains both termini of the proenzyme and lacks an internal fragment.[1]

References

  1. Evidence for protein splicing in the endoplasmic reticulum-Golgi intermediate compartment. Demirov, D., Sarafian, V., Kremensky, I., Ganev, V. Biochim. Biophys. Acta (1999) [Pubmed]
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