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MeSH Review

Protein Splicing

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Disease relevance of Protein Splicing


High impact information on Protein Splicing


Chemical compound and disease context of Protein Splicing


Biological context of Protein Splicing


Anatomical context of Protein Splicing


Associations of Protein Splicing with chemical compounds


Gene context of Protein Splicing


Analytical, diagnostic and therapeutic context of Protein Splicing

  • Genetic enhancement of RNA-processing defects by a dominant mutation in B52, the Drosophila gene for an SR protein splicing factor [29].
  • Using Western blot analysis with antisera raised against peptides derived from the non-homology region (NHR) and the N-terminal half of the PRS1 gene product it has been shown that the NHR is not removed by protein splicing [30].


  1. Evidence of selection for protein introns in the recAs of pathogenic mycobacteria. Davis, E.O., Thangaraj, H.S., Brooks, P.C., Colston, M.J. EMBO J. (1994) [Pubmed]
  2. Homing events in the gyrA gene of some mycobacteria. Fsihi, H., Vincent, V., Cole, S.T. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Reversible inhibition of protein splicing by zinc ion. Mills, K.V., Paulus, H. J. Biol. Chem. (2001) [Pubmed]
  4. Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation. Pradhan, S., Bacolla, A., Wells, R.D., Roberts, R.J. J. Biol. Chem. (1999) [Pubmed]
  5. Cross-reactivity between autoimmune anti-U1 snRNP antibodies and neutralizing epitopes of HIV-1 gp120/41. Douvas, A., Takehana, Y. AIDS Res. Hum. Retroviruses (1994) [Pubmed]
  6. Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Li, X., Manley, J.L. Cell (2005) [Pubmed]
  7. Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity. Duan, X., Gimble, F.S., Quiocho, F.A. Cell (1997) [Pubmed]
  8. In vitro protein splicing of purified precursor and the identification of a branched intermediate. Xu, M.Q., Southworth, M.W., Mersha, F.B., Hornstra, L.J., Perler, F.B. Cell (1993) [Pubmed]
  9. Sequence of introns and flanking exons in wild-type and box3 mutants of cytochrome b reveals an interlaced splicing protein coded by an intron. Lazowska, J., Jacq, C., Slonimski, P.P. Cell (1980) [Pubmed]
  10. Homing of a DNA endonuclease gene by meiotic gene conversion in Saccharomyces cerevisiae. Gimble, F.S., Thorner, J. Nature (1992) [Pubmed]
  11. Reactivity of the cysteine residues in the protein splicing active center of the Mycobacterium tuberculosis RecA intein. Shingledecker, K., Jiang, S., Paulus, H. Arch. Biochem. Biophys. (2000) [Pubmed]
  12. CUS1, a suppressor of cold-sensitive U2 snRNA mutations, is a novel yeast splicing factor homologous to human SAP 145. Wells, S.E., Neville, M., Haynes, M., Wang, J., Igel, H., Ares, M. Genes Dev. (1996) [Pubmed]
  13. Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation. Li, X., Wang, J., Manley, J.L. Genes Dev. (2005) [Pubmed]
  14. Regulation of alternative splicing of CD45 by antagonistic effects of SR protein splicing factors. ten Dam, G.B., Zilch, C.F., Wallace, D., Wieringa, B., Beverley, P.C., Poels, L.G., Screaton, G.R. J. Immunol. (2000) [Pubmed]
  15. Crystal structure of a mini-intein reveals a conserved catalytic module involved in side chain cyclization of asparagine during protein splicing. Ding, Y., Xu, M.Q., Ghosh, I., Chen, X., Ferrandon, S., Lesage, G., Rao, Z. J. Biol. Chem. (2003) [Pubmed]
  16. Identification of three core regions essential for protein splicing of the yeast Vma1 protozyme. A random mutagenesis study of the entire Vma1-derived endonuclease sequence. Kawasaki, M., Nogami, S., Satow, Y., Ohya, Y., Anraku, Y. J. Biol. Chem. (1997) [Pubmed]
  17. Antagonistic effects of retinoic acid and thyroid hormone on the expression of the tissue-specific splicing protein SmN in a clonal cell line derived from rat heart. Gerrelli, D., Huntriss, J.D., Latchman, D.S. J. Mol. Cell. Cardiol. (1994) [Pubmed]
  18. Immune recognition of a human renal cancer antigen through post-translational protein splicing. Hanada, K., Yewdell, J.W., Yang, J.C. Nature (2004) [Pubmed]
  19. CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy. Greenbaum, L.E., Li, W., Cressman, D.E., Peng, Y., Ciliberto, G., Poli, V., Taub, R. J. Clin. Invest. (1998) [Pubmed]
  20. Protein splicing of the yeast TFP1 intervening protein sequence: a model for self-excision. Cooper, A.A., Chen, Y.J., Lindorfer, M.A., Stevens, T.H. EMBO J. (1993) [Pubmed]
  21. Protein splicing: an analysis of the branched intermediate and its resolution by succinimide formation. Xu, M.Q., Comb, D.G., Paulus, H., Noren, C.J., Shao, Y., Perler, F.B. EMBO J. (1994) [Pubmed]
  22. Protein splicing in trans by purified N- and C-terminal fragments of the Mycobacterium tuberculosis RecA intein. Mills, K.V., Lew, B.M., Jiang, S., Paulus, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  23. Phosphorylated Ser/Arg-rich proteins: limiting factors in the assembly of 200S large nuclear ribonucleoprotein particles. Yitzhaki, S., Miriami, E., Sperling, R., Sperling, J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  24. Protein splicing converts the yeast TFP1 gene product to the 69-kD subunit of the vacuolar H(+)-adenosine triphosphatase. Kane, P.M., Yamashiro, C.T., Wolczyk, D.F., Neff, N., Goebl, M., Stevens, T.H. Science (1990) [Pubmed]
  25. Interaction of mammalian splicing factor SF3a with U2 snRNP and relation of its 60-kD subunit to yeast PRP9. Brosi, R., Gröning, K., Behrens, S.E., Lührmann, R., Krämer, A. Science (1993) [Pubmed]
  26. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. Buckanovich, R.J., Posner, J.B., Darnell, R.B. Neuron (1993) [Pubmed]
  27. The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome. Pinto, A.L., Steitz, J.A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  28. The splicing factor U1C represses EWS/FLI-mediated transactivation. Knoop, L.L., Baker, S.J. J. Biol. Chem. (2000) [Pubmed]
  29. Genetic enhancement of RNA-processing defects by a dominant mutation in B52, the Drosophila gene for an SR protein splicing factor. Peng, X., Mount, S.M. Mol. Cell. Biol. (1995) [Pubmed]
  30. PRS1 is a key member of the gene family encoding phosphoribosylpyrophosphate synthetase in Saccharomyces cerevisiae. Carter, A.T., Beiche, F., Hove-Jensen, B., Narbad, A., Barker, P.J., Schweizer, L.M., Schweizer, M. Mol. Gen. Genet. (1997) [Pubmed]
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