Disease relevance of Argimate

• Furthermore, in sporadic amyotrophic lateral sclerosis (sALS) the total aromatic amino acids, arginine, glutamate, threonine, and tyrosine were significantly elevated [1].

Psychiatry related information on Argimate

• Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction [2].
• The effects of yohimbine plus L-arginine glutamate on sexual arousal in postmenopausal women with sexual arousal disorder [3].

High impact information on Argimate

• In the medial and lateral preoptic area, calcium and nerve impulse dependent increases of arginine, glutamate and aspartate were observed during the first 2 min after formalin injection [4].
• These results indicate that the release of arginine, glutamate and aspartate may mediate rapid pain neural transmission in the VPL nucleus of the thalamus [5].
• Release of arginine, glutamate and glutamine in the hippocampus of freely moving rats: Involvement of nitric oxide [6].
• Plasma and brain levels of arginine and its metabolites in the arginine-glutamate pathway, and activities of 2 brain enzymes of this pathway: arginase (L-arginine amidohydrolase, EC3521) and ornithine amino-transferase (OAT, ornithine-oxo-acid aminotransferase, EC26113) were measured in these rats [7].
• Lysine-411 was mutagenized to arginine, glutamate, and leucine, and the mutant constructs (K411R-, K411E-, and K411L-hRFC, respectively) were transfected into hRFC-deficient K562 cells [8].

Anatomical context of Argimate

• Production of NO in the isolated organ of Corti and utricle or in the isolated vestibular and cochlear hair cells after stimulation with L-arginine, glutamate, GM and LPS was investigated using the fluorescence indicator 4,5-diaminofluorescein diacetate [9].

Analytical, diagnostic and therapeutic context of Argimate

• CONCLUSIONS: This pilot study shows that the on-demand oral administration of the L-arginine glutamate 6g and 6 mg yohimbine combination is effective in improving erectile function in patients with mild to moderate ED [2].

References