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Chemical Compound Review

Perazyl     1-[(4-chlorophenyl)-phenyl- methyl]-4...

Synonyms: Trihistan, Alergicide, Diparalene, Histantine, Piparalene, ...
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Disease relevance of Histantine


Psychiatry related information on Histantine


High impact information on Histantine


Chemical compound and disease context of Histantine


Biological context of Histantine


Anatomical context of Histantine

  • There was a time-dependent increase in the recovery of alveolar macrophages (AMs) from the lungs of the CZ-treated rats as well as in the phospholipid content of the cells [13].
  • Employing [3H]palmitate-labeled surfactant, it was shown that cells incubated with chlorocyclizine surfactant incorporated 46.2-73.0 nmol of fatty acids per mg protein and were transformed into foam cells [14].
  • Chlorcyclizine-induced glycosaminoglycan alterations resulted in quantifiable, region-specific differences in mesenchymal cell relationships to the basal lamina and in the ultrastructural appearance of the zone immediately subjacent to the basal lamina [12].

Associations of Histantine with other chemical compounds


Gene context of Histantine


  1. Chlorcyclizine induction of cleft palate in the rat: degradation of palatal glycosaminoglycans. Wilk, A.L., King, C.T., Pratt, R.M. Teratology (1978) [Pubmed]
  2. Failure of chlorcyclizine to induce cryptorchism in the pig fetus. Heyns, C.F. S. Afr. Med. J. (1985) [Pubmed]
  3. The effect of antihistamine drugs on the neuroleptic-induced catalepsy. Pawłowski, L., Sidorowicz, L. Polish journal of pharmacology and pharmacy. (1978) [Pubmed]
  4. Anticonvulsant effects of benzhydryl piperazines on maximal electroshock seizures in rats. Novack, G.D., Stark, L.G., Peterson, S.L. J. Pharmacol. Exp. Ther. (1979) [Pubmed]
  5. Effects of chlorcyclizine-induced glycosaminoglycan alterations on patterns of hyaluronate distribution during morphogenesis of the mouse secondary palate. Brinkley, L.L., Morris-Wiman, J. Development (1987) [Pubmed]
  6. Flare and itch induced by substance P in human skin. Hägermark, O., Hökfelt, T., Pernow, B. J. Invest. Dermatol. (1978) [Pubmed]
  7. Ligand interaction with the purified serotonin transporter in solution and at the air/water interface. Faivre, V., Manivet, P., Callaway, J.C., Airaksinen, M.M., Morimoto, H., Baszkin, A., Launay, J.M., Rosilio, V. FEBS Lett. (2000) [Pubmed]
  8. Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport. Kandimalla, K.K., Donovan, M.D. Journal of pharmaceutical sciences. (2005) [Pubmed]
  9. Effect of L-histidine and chlorcyclizine on apomorphine-induced climbing behaviour and methamphetamine stereotypy in mice. Joshi, V.V., Balsara, J.J., Jadhav, J.H., Chandorkar, A.G. Eur. J. Pharmacol. (1981) [Pubmed]
  10. Experimental teratogenicity of structurally similar compounds with or without piperazine-ring: a preliminary report. Druga, A., Nyitray, M., Szaszovszky, E. Polish journal of pharmacology and pharmacy. (1980) [Pubmed]
  11. Effects of chlorocyclizine on pulmonary lipid metabolism in rats. Stern, N., Tietz, A., Gaton, E., Wolman, M. Biochim. Biophys. Acta (1983) [Pubmed]
  12. The effects of chlorcyclizine-induced glycosaminoglycan alterations on palatal mesenchyme-basal lamina relationships in the mouse. Brinkley, L.L., Morris-Wiman, J. Am. J. Anat. (1986) [Pubmed]
  13. Chlorcyclizine--induced pulmonary phospholipidosis in rats. Reasor, M.J., Heyneman, C.A., Walker, E.R. Res. Commun. Chem. Pathol. Pharmacol. (1982) [Pubmed]
  14. The catabolism of lung surfactant by alveolar macrophages. Stern, N., Riklis, S., Kalina, M., Tietz, A. Biochim. Biophys. Acta (1986) [Pubmed]
  15. Quantitative enantiomeric analysis of chlorcyclizine, hydroxyzine, and meclizine by capillary electrophoresis. Ho, Y., Wu, H., Wu, S., Chen, S., Kou, H. Analytical and bioanalytical chemistry. (2003) [Pubmed]
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