Disease relevance of Histantine

• Chlorcyclizine induction of cleft palate in the rat: degradation of palatal glycosaminoglycans [1].
• Failure of chlorcyclizine to induce cryptorchism in the pig fetus [2].
• The effect of atropine on the spiperone- or reserpine-induced catalepsy was compared with the effect pure antihistamines (chlorcyclizine, diphenhydramine, mepyramine) and antiserotonin -- antihistamine drugs (cyproheptadine, danitracen) [3].

Psychiatry related information on Histantine

• The anticonvulsant effects of four benzhydryl piperazines, SC-13504 (ropizine, an anticonvulsant), hydroxyzine (HDX, an anxiolytic), chlorcyclizine (CCZ, an antihistaminic) and buclizine (BUC, an antihistaminic), were investigated utilizing a modified maximal electroshock seizure test in rats [4].

High impact information on Histantine

• Effects of chlorcyclizine-induced glycosaminoglycan alterations on patterns of hyaluronate distribution during morphogenesis of the mouse secondary palate [5].
• These responses were inhibited by oral pretreatment of the subjects with an antihistaminic drug (chlorcyclizine) or by local pretreatment with Compound 48/80 administered to deplete the local stores of mast-cell bound histamine [6].
• Whereas an unrelated drug (chlorcyclizine) did not bind to the spread SERT, it interacted with its specific ligands [7].
• The submucosal to mucosal fluxes (J(s-m)) of chlorcyclizine and chlorpheniramine across the olfactory mucosa were significantly greater than the mucosal to submucosal fluxes (J(m-s)) [8].
• Pretreatment with L-histidine (850 and 1000 mh/kg, i.p.), a precursor of brain histamine, and chlorcyclizine (25 and 50 mg/kg, i.p.), a H1-receptor blocker, failed to modify apomorphine-induced climbing behaviour in mice [9].

Chemical compound and disease context of Histantine

• Administration of the cleft palate teratogen chlorcyclizine or norchlorcyclizine to pregnant rats causes an alteration in glycosaminoglycans (GAGs) in embryonic palatal shelves [1].
• Perphenazine and chlorcyclizine, as alkyl-piperazine derivatives induced cleft palate and micromelia, while chlorpromazine and thenalidine did not [10].

Biological context of Histantine

• Effects of chlorocyclizine on pulmonary lipid metabolism in rats [11].
• Pregnant CD-1 mice were gavaged with chlorcyclizine on days 10.5, 11.5, and 12.5 of gestation, and the fetuses were harvested on day 13 [12].

Anatomical context of Histantine

• There was a time-dependent increase in the recovery of alveolar macrophages (AMs) from the lungs of the CZ-treated rats as well as in the phospholipid content of the cells [13].
• Employing [3H]palmitate-labeled surfactant, it was shown that cells incubated with chlorocyclizine surfactant incorporated 46.2-73.0 nmol of fatty acids per mg protein and were transformed into foam cells [14].
• Chlorcyclizine-induced glycosaminoglycan alterations resulted in quantifiable, region-specific differences in mesenchymal cell relationships to the basal lamina and in the ultrastructural appearance of the zone immediately subjacent to the basal lamina [12].

Associations of Histantine with other chemical compounds

• Enantioseparation of chlorcyclizine, hydroxyzine, and meclizine was performed in glycine buffer (0.6 mol L(-1); pH 3.00) with sulfated beta-cyclodextrin (5 mg mL(-1)) as a chiral selector; and the separated drugs were monitored by ultra-violet detector [15].
• Quantitative enantiomeric analysis of chlorcyclizine, hydroxyzine, and meclizine by capillary electrophoresis [15].
• Alveolar macrophages, incubated in vitro with normal and chlorocyclizine surfactants hydrolyzed the surfactant phospholipids and incorporated the fatty acids into cellular triacylglycerol [14].

Gene context of Histantine

• Chlorcyclizine-induced alterations of the extracellular matrix were used to investigate the possible contribution of extracellular matrix to these differences [12].

References