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CEBPE  -  CCAAT/enhancer binding protein (C/EBP),...

Homo sapiens

Synonyms: C/EBP epsilon, C/EBP-epsilon, CCAAT/enhancer-binding protein epsilon, CRP1
 
 
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Disease relevance of CEBPE

 

High impact information on CEBPE

 

Biological context of CEBPE

  • We examined the human CEBPE-regulatory pathway by unbiased reference and custom gene expression assays [7].
  • DNA sequence analysis reveals that the gene encodes a protein highly homologous to rat CRP1 [6].
 

Anatomical context of CEBPE

  • Thus, the myeloid-restricted nature of CEBPE precludes the expression of RETN in human adipocytes which, however, are targeted by this innate immune-derived proinflammatory cytokine [7].
  • Real-time RT-PCR analysis demonstrated lack of both the transcriptional factor CEBPE and RETN expression in adipose and muscle cells [7].
  • Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors [8].
  • Mouse Cebpe and Retnlg were predictably expressed in macrophages, whereas Retn was abundant in adipocytes [7].
 

Other interactions of CEBPE

  • Cysteine-rich LIM-only proteins, CRP1 and CRP2, expressed during cardiovascular development act as bridging molecules that associate with serum response factor and GATA proteins [8].

References

  1. DNase I hypersensitivity analysis of the human CCAAT enhancer binding protein epsilon (C/EBPepsilon) gene. Kubota, T., Hirama, T., Verbeek, W., Kawano, S., Chih, D.Y., Chumakov, A.M., Taguchi, H., Koeffler, H.P. Leuk. Res. (2001) [Pubmed]
  2. C/EBP epsilon mediates myeloid differentiation and is regulated by the CCAAT displacement protein (CDP/cut). Khanna-Gupta, A., Zibello, T., Sun, H., Lekstrom-Himes, J., Berliner, N. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Increased CCAAT Enhancer-binding Protein {epsilon} (C/EBP{epsilon}) Expression and Premature Apoptosis in Myeloid Cells Expressing Gfi-1 N382S Mutant Associated with Severe Congenital Neutropenia. Zhuang, D., Qiu, Y., Kogan, S.C., Dong, F. J. Biol. Chem. (2006) [Pubmed]
  4. Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein. Du, J., Stankiewicz, M.J., Liu, Y., Xi, Q., Schmitz, J.E., Lekstrom-Himes, J.A., Ackerman, S.J. J. Biol. Chem. (2002) [Pubmed]
  5. Identification of a functional androgen-response element in the exon 1-coding sequence of the cystatin-related protein gene crp2. Devos, A., Claessens, F., Alen, P., Winderickx, J., Heyns, W., Rombauts, W., Peeters, B. Mol. Endocrinol. (1997) [Pubmed]
  6. A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus. Antonson, P., Stellan, B., Yamanaka, R., Xanthopoulos, K.G. Genomics (1996) [Pubmed]
  7. Human Resistin Is a Systemic Immune-Derived Proinflammatory Cytokine Targeting both Leukocytes and Adipocytes. Nagaev, I., Bokarewa, M., Tarkowski, A., Smith, U. PLoS ONE (2006) [Pubmed]
  8. Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. Chang, D.F., Belaguli, N.S., Iyer, D., Roberts, W.B., Wu, S.P., Dong, X.R., Marx, J.G., Moore, M.S., Beckerle, M.C., Majesky, M.W., Schwartz, R.J. Dev. Cell (2003) [Pubmed]
 
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