The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Arhgap5  -  Rho GTPase activating protein 5

Mus musculus

Synonyms: Rho GTPase-activating protein 5, Rho-type GTPase-activating protein 5, Rhogap5, p190-B, p190B
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Arhgap5

  • Moreover, we suggest that alterations in tissue architecture and the adjacent stroma as a consequence of p190-B overexpression during pregnancy leads to loss of growth control and the formation of hyperplasia [1].
 

High impact information on Arhgap5

  • The activation state of Rho following IGF-1 signaling is determined by the tyrosine-phosphorylation status of p190-B RhoGAP and its resulting subcellular relocalization [2].
  • These observations strongly suggest that SHP-2 dephosphorylates p190-B RhoGAP, leading to the activation of RhoA [3].
  • During myogenesis, p190-B RhoGAP was tyrosyl dephosphorylated concomitant with the stimulation of SHP-2's phosphatase activity [3].
  • An increase in collagen and extensive infiltration of macrophages, which have recently been implicated in branching morphogenesis, is observed in the stroma surrounding the p190-B-overexpressing TEBs [1].
  • Short-term induction of p190-B in the developing mammary gland results in abnormal terminal end buds (TEBs) that exhibit aberrant budding off the neck, histological anomalies, and a markedly thickened stroma [1].
 

Biological context of Arhgap5

  • Together, these results suggest that p190-B regulates ductal morphogenesis, at least in part, by modulating the IGF signaling axis [4].
  • A haploinsufficiency phenotype was observed in p190-B heterozygous mice as indicated by decreased number and rate of ductal outgrowth(s) at 3, 4, and 5 wk of age when compared with their wild-type littermates [4].
  • The high level of sequence homology between the human and the mouse suggests that there is a strong selective pressure to maintain the p190-B protein structure [5].
  • In p190-B RhoGAP-deficient mice, CREB phosphorylation is substantially reduced in embryonic tissues [6].
 

Anatomical context of Arhgap5

  • These findings are consistent with decreased IGF signaling observed previously in p190-B-/- mouse embryo fibroblasts [4].
 

Associations of Arhgap5 with chemical compounds

 

Regulatory relationships of Arhgap5

  • Moreover, overexpression of a catalytically inactive mutant of SHP-2 inhibited p190-B RhoGAP tyrosyl dephosphorylation, RhoA activity, and myogenesis [3].
 

Other interactions of Arhgap5

  • By using SHP-2 substrate-trapping mutants, we identified p190-B RhoGAP as a SHP-2 substrate [3].
  • Interestingly, a single 3.9 kb exon was found to contain approx. 80% of the coding region of the mouse p190-B protein (amino acid residues 1-1238) including the 5'-untranslated region, the N-terminal GTPase domain and a middle domain of unknown function [5].

References

  1. P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland. Vargo-Gogola, T., Heckman, B.M., Gunther, E.J., Chodosh, L.A., Rosen, J.M. Mol. Endocrinol. (2006) [Pubmed]
  2. Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Sordella, R., Jiang, W., Chen, G.C., Curto, M., Settleman, J. Cell (2003) [Pubmed]
  3. SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway. Kontaridis, M.I., Eminaga, S., Fornaro, M., Zito, C.I., Sordella, R., Settleman, J., Bennett, A.M. Mol. Cell. Biol. (2004) [Pubmed]
  4. p190-B RhoGAP regulates mammary ductal morphogenesis. Chakravarty, G., Hadsell, D., Buitrago, W., Settleman, J., Rosen, J.M. Mol. Endocrinol. (2003) [Pubmed]
  5. Cloning, genomic organization and chromosomal assignment of the mouse p190-B gene. Burbelo, P.D., Finegold, A.A., Kozak, C.A., Yamada, Y., Takami, H. Biochim. Biophys. Acta (1998) [Pubmed]
  6. Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development. Sordella, R., Classon, M., Hu, K.Q., Matheson, S.F., Brouns, M.R., Fine, B., Zhang, L., Takami, H., Yamada, Y., Settleman, J. Dev. Cell (2002) [Pubmed]
  7. Distinct but Overlapping Functions for the Closely Related p190 RhoGAPs in Neural Development. Matheson, S.F., Hu, K.Q., Brouns, M.R., Sordella, R., Vanderheide, J.D., Settleman, J. Dev. Neurosci. (2006) [Pubmed]
 
WikiGenes - Universities