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Gene Review

DHCR24  -  24-dehydrocholesterol reductase

Homo sapiens

Synonyms: 3-beta-hydroxysterol delta-24-reductase, DCE, Delta(24)-sterol reductase, Diminuto/dwarf1 homolog, KIAA0018, ...
 
 
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Disease relevance of DHCR24

 

Psychiatry related information on DHCR24

 

High impact information on DHCR24

 

Chemical compound and disease context of DHCR24

 

Biological context of DHCR24

 

Anatomical context of DHCR24

  • In PC12 cell clones that were selected for resistance against AD-associated amyloid-beta peptide (Abeta)-induced toxicity, both mRNA and protein levels of seladin-1 were approximately threefold higher as compared with the non-resistant wild-type cells [7].
  • These original results demonstrate for the first time that seladin-1 is abundantly expressed by stem cells and appear to suggest that reduced expression in AD might be due to an altered pool of multipotent cells [4].
  • Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1 [4].
  • Although seladin-1 is expressed in the pituitary gland, no study addressed the expression or the function of this gene in pituitary adenomas [6].
  • Because the hippocampus and the subventricular zone, which are affected in AD, are the unique regions containing stem cells with neurogenic potential in the adult brain, it might be hypothesized that this multipotent cell compartment is the predominant source of seladin-1 in normal brain [4].
 

Associations of DHCR24 with chemical compounds

  • Both parents had mildly increased levels of desmosterol in plasma (mother: 1.4 mcg/ml; father: 1.8 mcg/ml), consistent with heterozygosity for DHCR24 deficiency [9].
  • Furthermore, we evaluated by quantitative real-time RT-PCR whether estrogen/SERMs modulate the expression of the recently discovered seladin-1 (selective AD indicator-1) gene, which exerts neuroprotective effects and is down-regulated in AD-vulnerable brain regions [5].
  • Conversely, 10 and 100 nm raloxifene reduced the expression of seladin-1 [5].
  • This ACTH-induced relocalization was abrogated by the pre-treatment of cells with 75 nM U18666A (an inhibitor of Seladin-1) [10].
  • Results also suggest that depending on its cellular localization, the Delta24-reductase activity of Seladin-1 may play a major role in steroid secretion in the adrenal gland [10].
 

Other interactions of DHCR24

 

Analytical, diagnostic and therapeutic context of DHCR24

References

  1. Expression of the novel adrenocorticotropin-responsive gene selective Alzheimer's disease indicator-1 in the normal adrenal cortex and in adrenocortical adenomas and carcinomas. Luciani, P., Ferruzzi, P., Arnaldi, G., Crescioli, C., Benvenuti, S., Nesi, G., Valeri, A., Greeve, I., Serio, M., Mannelli, M., Peri, A. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  2. DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis. Di Stasi, D., Vallacchi, V., Campi, V., Ranzani, T., Daniotti, M., Chiodini, E., Fiorentini, S., Greeve, I., Prinetti, A., Rivoltini, L., Pierotti, M.A., Rodolfo, M. Int. J. Cancer (2005) [Pubmed]
  3. Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. Waterham, H.R., Koster, J., Romeijn, G.J., Hennekam, R.C., Vreken, P., Andersson, H.C., FitzPatrick, D.R., Kelley, R.I., Wanders, R.J. Am. J. Hum. Genet. (2001) [Pubmed]
  4. Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1. Benvenuti, S., Saccardi, R., Luciani, P., Urbani, S., Deledda, C., Cellai, I., Francini, F., Squecco, R., Rosati, F., Danza, G., Gelmini, S., Greeve, I., Rossi, M., Maggi, R., Serio, M., Peri, A. Exp. Cell Res. (2006) [Pubmed]
  5. Estrogen and selective estrogen receptor modulators exert neuroprotective effects and stimulate the expression of selective Alzheimer's disease indicator-1, a recently discovered antiapoptotic gene, in human neuroblast long-term cell cultures. Benvenuti, S., Luciani, P., Vannelli, G.B., Gelmini, S., Franceschi, E., Serio, M., Peri, A. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  6. Expression of the antiapoptotic gene seladin-1 and octreotide-induced apoptosis in growth hormone-secreting and nonfunctioning pituitary adenomas. Luciani, P., Gelmini, S., Ferrante, E., Lania, A., Benvenuti, S., Baglioni, S., Mantovani, G., Cellai, I., Ammannati, F., Spada, A., Serio, M., Peri, A. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  7. The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. Greeve, I., Hermans-Borgmeyer, I., Brellinger, C., Kasper, D., Gomez-Isla, T., Behl, C., Levkau, B., Nitsch, R.M. J. Neurosci. (2000) [Pubmed]
  8. Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease. Iivonen, S., Hiltunen, M., Alafuzoff, I., Mannermaa, A., Kerokoski, P., Puoliväli, J., Salminen, A., Helisalmi, S., Soininen, H. Neuroscience (2002) [Pubmed]
  9. Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay. Andersson, H.C., Kratz, L., Kelley, R. Am. J. Med. Genet. (2002) [Pubmed]
  10. Seladin-1 expression in rat adrenal gland: effect of adrenocorticotropic hormone treatment. Battista, M.C., Roberge, C., Otis, M., Gallo-Payet, N. J. Endocrinol. (2007) [Pubmed]
  11. Seladin-1 as a target of estrogen receptor activation in the brain: a new gene for a rather old story? Peri, A., Danza, G., Serio, M. J. Endocrinol. Invest. (2005) [Pubmed]
 
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