High impact information on Pstpip1

• Following various stimuli, such as concanavalin A, anti-TCRbeta, anti-CD3epsilon, anti-CD3epsilon/phorbol myristate acetate (PMA), IL-2, or PMA/ionomycin, PSTPIP and CD2 expression, as well as their association, increased in a time-dependent fashion [1].
• There was no direct association between CD3epsilon or CD28 and PSTPIP [1].
• Regulation of the association between PSTPIP and CD2 in murine T cells [1].
• Tyrosine phosphorylated PSTPIP bound poorly to CD2 compared to dephosphorylated PSTPIP, and protein tyrosine phosphatase was shown to affect both phosphorylation of PSTPIP and the CD2-PSTPIP association [1].

Associations of Pstpip1 with chemical compounds

• In the current study, we investigated CD2 and PSTPIP (proline, serine, threonine phosphatase interacting protein, murine homologue of CD2BP1) interactions in purified mouse splenic T cells [1].

Analytical, diagnostic and therapeutic context of Pstpip1

• CD2 and CD4 ligation reciprocally regulated their association with PSTPIP [1].

References