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ENO3  -  enolase 3 (beta, muscle)

Homo sapiens

Synonyms: 2-phospho-D-glycerate hydro-lyase, Beta-enolase, Enolase 3, GSD13, MSE, ...
 
 
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Disease relevance of ENO3

 

Psychiatry related information on ENO3

  • Here we report the results of the first extensive study of beta enolase expression during human development [6].
  • DESIGN: Cross-sectional study on adults from Western India. SETTING: Rural, semi urban, urban higher/middle/lower socioeconomic regions (HSE/MSE/LSE) having diverse dietary habits and environmental conditions [7].
  • OBJECTIVES: Regular access to a multi-sensory environment (MSE or Snoezelen room) was compared with a non-complex sensory environment for individuals with learning disabilities [8].
  • Exercise tolerance was assessed objectively by percent predicted cycle power output (%PO), and subjectively by a self-efficacy questionnaire for ambulatory (ASE) and muscular (MSE) items and by a disease-specific, health-related, quality-of-life questionnaire (HRQL) [9].
 

High impact information on ENO3

  • A regulatory element upstream of the human myoglobin gene functions as a muscle-specific enhancer (MSE) in conjunction with core promoter elements of the myoglobin gene, but not in combination with the simian virus 40 (SV40) early promoter [10].
  • We conclude that mammalian TATA-box elements are functionally heterogeneous, and suggest that this heterogeneity reflects differential interactions with distinctive TATA box-binding factors, only some of which can act cooperatively with MSE-binding proteins to generate an active transcriptional complex [10].
  • In adult human muscle, over 90% of enolase activity is accounted for by the beta-enolase subunit, the protein product of the ENO3 gene [1].
  • The ENO3 gene of our patient carries two heterozygous missense mutations affecting highly conserved amino acid residues; a G467A transition changing a glycine residue at position 156 to aspartate, in close proximity to the catalytic site, and a G1121A transition changing a glycine to glutamate at position 374 [1].
  • We demonstrated that all five of these proteins specifically activate exon inclusion of cardiac troponin T minigenes in vivo via muscle-specific splicing enhancer (MSE) sequences [11].
 

Chemical compound and disease context of ENO3

  • In this paper, we describe analyses of the muscle-specific pyruvate kinase-M and beta-enolase promoters that implicate additional mechanisms for the regulation of glycolytic enzyme gene transcription by hypoxia [4].
  • RECENT FINDINGS: New inherited defects are still being discovered, such as the beta-enolase deficiency in glycogenosis type XIII and mutations in the gene encoding an esterase/lipase/thioesterase protein in Chanarin-Dorfman syndrome, a multisystem triglyceride storage disease [12].
  • These data imply that serum beta-enolase may be a more effective marker for early myocardial infarction, particularly in milder cases, than measurement of creatine kinase activity [13].
  • Crude ethanolic extract of Indian medicinal plant, Desmodium gangeticum (A001) and its three fractions-hexane (F002), n-butanol (F003) and aqueous (F004) were evaluated chemoprophylactically and chemotherapeutically against experimental visceral leishmaniasis in hamsters [14].
 

Biological context of ENO3

 

Anatomical context of ENO3

 

Associations of ENO3 with chemical compounds

  • A purified human serum protein previously named "modifying protein," which is responsible for the modification of creatine kinase-M and alpha-enolase subunits, modifies beta beta enolase and also has a pH-activity profile identical to that for serum [20].
  • Under acid conditions, ethylene oxide was found to be oxidized on the platinum oxide surface at +550 mV vs MSE, thus enabling its monitoring via the measurement of the associated current [21].
  • Diets contained either i) margarine (M), ii) margarine with phytosterol esters (MSE) (1.84 g/d), or iii) margarine with phytostanol esters (MSA) (1.84 g/d) [22].
  • Plasma total cholesterol level at d 21/22 was lower (P < 0. 05) for MSE (13.4%) but not MSA (10.2%) versus M (6.0%) diets [22].
  • Near-point testing revealed less residual accommodation with cyclopentolate (difference in MSE, OD=-0.27 +/- 0.51 D, t=2.68, P=.006; OS=-0.32 +/- 0.49 D, t=3.46, P=.001) [23].
 

Other interactions of ENO3

 

Analytical, diagnostic and therapeutic context of ENO3

References

  1. Beta-enolase deficiency, a new metabolic myopathy of distal glycolysis. Comi, G.P., Fortunato, F., Lucchiari, S., Bordoni, A., Prelle, A., Jann, S., Keller, A., Ciscato, P., Galbiati, S., Chiveri, L., Torrente, Y., Scarlato, G., Bresolin, N. Ann. Neurol. (2001) [Pubmed]
  2. In situ distribution of enolase isozymes in chronic liver disease. Fukuda, Y., Miyazawa, Y., Imoto, M., Koyama, Y., Nakano, I., Nagura, H., Kato, K. Am. J. Gastroenterol. (1989) [Pubmed]
  3. Enolase isozymes as markers for differential diagnosis of neuroblastoma, rhabdomyosarcoma, and Wilms' tumor. Ishiguro, Y., Kato, K., Ito, T., Horisawa, M., Nagaya, M. Gann = Gan. (1984) [Pubmed]
  4. Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element. Discher, D.J., Bishopric, N.H., Wu, X., Peterson, C.A., Webster, K.A. J. Biol. Chem. (1998) [Pubmed]
  5. Identification of the 49-kDa autoantigen associated with lymphocytic hypophysitis as alpha-enolase. O'Dwyer, D.T., Smith, A.I., Matthew, M.L., Andronicos, N.M., Ranson, M., Robinson, P.J., Crock, P.A. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  6. The muscle-specific enolase is an early marker of human myogenesis. Fougerousse, F., Edom-Vovard, F., Merkulova, T., Ott, M.O., Durand, M., Butler-Browne, G., Keller, A. J. Muscle Res. Cell. Motil. (2001) [Pubmed]
  7. Are lifestyle factors good predictors of retinol and vitamin C deficiency in apparently healthy adults? Chiplonkar, S.A., Agte, V.V., Mengale, S.S., Tarwadi, K.V. European journal of clinical nutrition. (2002) [Pubmed]
  8. Behavioural effects of long-term multi-sensory stimulation. Martin, N.T., Gaffan, E.A., Williams, T. The British journal of clinical psychology / the British Psychological Society. (1998) [Pubmed]
  9. Time course of recovery during cardiac rehabilitation. Foster, C., Oldridge, N.B., Dion, W., Forsyth, G., Grevenow, P., Hansen, M., Laughlin, J., Plichta, C., Rabas, S., Sharkey, R.E. Journal of cardiopulmonary rehabilitation. (1995) [Pubmed]
  10. Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer. Wefald, F.C., Devlin, B.H., Williams, R.S. Nature (1990) [Pubmed]
  11. CELF6, a member of the CELF family of RNA-binding proteins, regulates muscle-specific splicing enhancer-dependent alternative splicing. Ladd, A.N., Nguyen, N.H., Malhotra, K., Cooper, T.A. J. Biol. Chem. (2004) [Pubmed]
  12. Metabolic and drug-induced muscle disorders. Scarlato, G., Comi, G.P. Curr. Opin. Neurol. (2002) [Pubmed]
  13. Serum beta-enolase in acute myocardial infarction. Nomura, M., Kato, K., Nagasaka, A., Shiga, Y., Miyagi, Y., Fukui, R., Nakano, H., Abo, Y., Okajima, S., Nakai, A. British heart journal. (1987) [Pubmed]
  14. Efficacy of Desmodium gangeticum extract and its fractions against experimental visceral leishmaniasis. Singh, N., Mishra, P.K., Kapil, A., Arya, K.R., Maurya, R., Dube, A. Journal of ethnopharmacology. (2005) [Pubmed]
  15. Methylation patterns in the human muscle-specific enolase gene (ENO3). Peshavaria, M., Day, I.N. Biochem. J. (1993) [Pubmed]
  16. Molecular structure of the human muscle-specific enolase gene (ENO3). Peshavaria, M., Day, I.N. Biochem. J. (1991) [Pubmed]
  17. Nucleotide sequence of a cDNA encoding the human muscle-specific enolase (MSE). Calì, L., Feo, S., Oliva, D., Giallongo, A. Nucleic Acids Res. (1990) [Pubmed]
  18. Beta-enolase in blood plasma during open heart surgery. Usui, A., Kato, K., Abe, T., Murase, M., Tanaka, M., Takeuchi, E. Cardiovasc. Res. (1989) [Pubmed]
  19. Enolase isoenzymes in benign and malignant melanocytic lesions. Royds, J.A., Parsons, M.A., Rennie, I.G., Timperley, W.R., Taylor, C.B. Diagnostic histopathology / published in association with the Pathological Society of Great Britain and Ireland. (1982) [Pubmed]
  20. Postsynthetic modification of human enolase isoenzymes. Rigiani, N.R., Wevers, R.A., Rijk, E., Soons, J.B. Clin. Chem. (1987) [Pubmed]
  21. Amperometric sensing of ethylene oxide in the gas phase. Hodgson, A.W., Jacquinot, P., Hauser, P.C. Anal. Chem. (2000) [Pubmed]
  22. Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters. Jones, P.J., Raeini-Sarjaz, M., Ntanios, F.Y., Vanstone, C.A., Feng, J.Y., Parsons, W.E. J. Lipid Res. (2000) [Pubmed]
  23. Comparison of tropicamide and cyclopentolate for cycloplegic refractions in myopic adult refractive surgery patients. Hofmeister, E.M., Kaupp, S.E., Schallhorn, S.C. Journal of cataract and refractive surgery. (2005) [Pubmed]
  24. Immunohistochemical study of carbonic anhydrase III in the extraocular muscles of human embryos. Oguni, M., Setogawa, T., Tanaka, O., Shinohara, H., Kato, K. Acta anatomica. (1992) [Pubmed]
  25. Comparison of beta enolase and myoglobin as histological markers of rhabdomyosarcoma. Royds, J.A., Variend, S., Timperley, W.R., Taylor, C.B. J. Clin. Pathol. (1985) [Pubmed]
  26. Myoid cells in the human thymus and thymoma revealed by three different immunohistochemical markers for striated muscle. Sato, T., Tamaoki, N. Acta Pathol. Jpn. (1989) [Pubmed]
  27. Antibodies against human muscle enolase recognize a 45-kDa bacterial cell wall outer membrane enolase-like protein. Witkowska, D., Pietkiewicz, J., Szostko, B., Danielewicz, R., Masłowski, L., Gamian, A. FEMS Immunol. Med. Microbiol. (2005) [Pubmed]
  28. Psychological and somatic subjective symptoms as a result of dermatological patch testing with metallic mercury and phenyl mercuric acetate. Marcusson, J.A. Toxicol. Lett. (1996) [Pubmed]
 
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