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Gene Review

Slfn1  -  schlafen 1

Mus musculus

Synonyms: AV316259
 
 
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Disease relevance of Slfn1

 

High impact information on Slfn1

 

Biological context of Slfn1

 

Anatomical context of Slfn1

 

Other interactions of Slfn1

  • Overexpression of cyclin D1 in growth-arrested, Slfn-1-expressing cells induced an increase in cell growth consistent with this protein being the biological target of Slfn-1 [2].

References

  1. Schlafen, a new family of growth regulatory genes that affect thymocyte development. Schwarz, D.A., Katayama, C.D., Hedrick, S.M. Immunity (1998) [Pubmed]
  2. Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1. Brady, G., Boggan, L., Bowie, A., O'Neill, L.A. J. Biol. Chem. (2005) [Pubmed]
  3. The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11. Bell, T.A., de la Casa-Esperón, E., Doherty, H.E., Ideraabdullah, F., Kim, K., Wang, Y., Lange, L.A., Wilhemsen, K., Lange, E.M., Sapienza, C., de Villena, F.P. Genetics (2006) [Pubmed]
  4. Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis. Fujikado, N., Saijo, S., Iwakura, Y. Arthritis Res. Ther. (2006) [Pubmed]
  5. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Geserick, P., Kaiser, F., Klemm, U., Kaufmann, S.H., Zerrahn, J. Int. Immunol. (2004) [Pubmed]
 
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