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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Tead4  -  TEA domain family member 4

Mus musculus

Synonyms: ETF-related factor 2, ETFR-2, ETFR-2a, Etfr2, FR-19, ...
 
 
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High impact information on Tead4

  • Although TEF-1 itself has little effect on the alpha(1)-adrenergic activation of skeletal muscle alpha-actin, the related factor RTEF-1 augments the response and is a target of alpha(1)-adrenergic signaling [1].
  • Identification of the functional domain in the transcription factor RTEF-1 that mediates alpha 1-adrenergic signaling in hypertrophied cardiac myocytes [2].
  • Mutation of a single serine residue, Ser-322, reduced the alpha(1)-adrenergic activation of RTEF-1 by 70% without affecting protein stability, suggesting that phosphorylation at this serine residue accounts for most of the alpha(1)-adrenergic response [2].
 

Other interactions of Tead4

  • In contrast, alpha(1)-adrenergic stimulation did not alter, and phosphatase treatment increased, MCAT binding of TEF-1 and RTEF-1 [1].
 

Analytical, diagnostic and therapeutic context of Tead4

References

  1. Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes. Maeda, T., Mazzulli, J.R., Farrance, I.K., Stewart, A.F. J. Biol. Chem. (2002) [Pubmed]
  2. Identification of the functional domain in the transcription factor RTEF-1 that mediates alpha 1-adrenergic signaling in hypertrophied cardiac myocytes. Ueyama, T., Zhu, C., Valenzuela, Y.M., Suzow, J.G., Stewart, A.F. J. Biol. Chem. (2000) [Pubmed]
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