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Gene Review

Mib1  -  mindbomb homolog 1 (Drosophila)

Mus musculus

Synonyms: DAPK-interacting protein 1, DIP-1, Dip1, E3 ubiquitin-protein ligase MIB1, E430019M12Rik, ...
 
 
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High impact information on Mib1

  • Interestingly, in the Mib1-/- mutants, Dll1 accumulated in the plasma membrane, while it was localized in the cytoplasm near the nucleus in the wild types, indicating that Mib1 is essential for the endocytosis of Notch ligand [1].
  • The DIP1 genome, however, appears to be generated from a different recombination event which results in the formation of a new distinct hybrid ORF [2].
 

Biological context of Mib1

  • As histopathology revealed a strong neurogenic phenotype, this study concentrates on characterizing the Mib1 mutant by analyzing Notch pathway components in embryonic neuroepithelium prior to developmental arrest [3].
 

Analytical, diagnostic and therapeutic context of Mib1

  • We analysed the tumours and the non-neoplastic control tissues by immunohistochemistry using antibodies directed against the CK2 subunits and against the proliferation marker Mib [4].

References

  1. Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Koo, B.K., Lim, H.S., Song, R., Yoon, M.J., Yoon, K.J., Moon, J.S., Kim, Y.W., Kwon, M.C., Yoo, K.W., Kong, M.P., Lee, J., Chitnis, A.B., Kim, C.H., Kong, Y.Y. Development (2005) [Pubmed]
  2. Genetic complexity of EHV-1 defective interfering particles and identification of novel IR4/UL5 hybrid proteins produced during persistent infection. Ebner, P.D., O'Callaghan, D.J. Virus Genes (2006) [Pubmed]
  3. Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling. Barsi, J.C., Rajendra, R., Wu, J.I., Artzt, K. Mech. Dev. (2005) [Pubmed]
  4. Influence of indomethacin and difluoromethylornithine on human tumour growth in nude mice. Siemer, S., Kriener, S., König, J., Remberger, K., Issinger, O.G. Eur. J. Cancer (1995) [Pubmed]
 
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