Gene Review:
KAT2A - K(lysine) acetyltransferase 2A
Homo sapiens
Synonyms:
GCN5, GCN5L2, General control of amino acid synthesis protein 5-like 2, HGCN5, Histone acetyltransferase GCN5, ...
- Trichostatin A regulates hGCN5 expression and cell cycle on daudi cells in vitro. Liu, H., Chen, Y., Cui, G., Wu, G., Wang, T., Hu, J. J. Huazhong Univ. Sci. Technol. Med. Sci. (2006)
- SWI/SNF binding to the HO promoter requires histone acetylation and stimulates TATA-binding protein recruitment. Mitra, D., Parnell, E.J., Landon, J.W., Yu, Y., Stillman, D.J. Mol. Cell. Biol. (2006)
- A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription. Barlev, N.A., Emelyanov, A.V., Castagnino, P., Zegerman, P., Bannister, A.J., Sepulveda, M.A., Robert, F., Tora, L., Kouzarides, T., Birshtein, B.K., Berger, S.L. Mol. Cell. Biol. (2003)
- Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Xu, W., Edmondson, D.G., Roth, S.Y. Mol. Cell. Biol. (1998)
- Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF. Moore, S.D., Herrick, S.R., Ince, T.A., Kleinman, M.S., Cin, P.D., Morton, C.C., Quade, B.J. Cancer Res. (2004)
- The VP16 Activation Domain Establishes an Active Mediator Lacking CDK8 in Vivo. Uhlmann, T., Boeing, S., Lehmbacher, M., Meisterernst, M. J. Biol. Chem. (2007)
- The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern. Carter, K.C., Wang, L., Shell, B.K., Zamir, I., Berger, S.L., Moore, P.A. Genomics (1997)
- Histone acetylase GCN5 enters the nucleus via importin-alpha in protozoan parasite Toxoplasma gondii. Bhatti, M.M., Sullivan, W.J. J. Biol. Chem. (2005)
- Fluorescence analysis of a dynamic loop in the PCAF/GCN5 histone acetyltransferase. Zheng, Y., Mamdani, F., Toptygin, D., Brand, L., Stivers, J.T., Cole, P.A. Biochemistry (2005)
- P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein. Senyuk, V., Sinha, K.K., Chakraborty, S., Buonamici, S., Nucifora, G. Biochem. Biophys. Res. Commun. (2003)
- GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Lerin, C., Rodgers, J.T., Kalume, D.E., Kim, S.H., Pandey, A., Puigserver, P. Cell metabolism. (2006)
- GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. Kelly, T.J., Lerin, C., Haas, W., Gygi, S.P., Puigserver, P. J. Biol. Chem. (2009)
- Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain. Hudson, B.P., Martinez-Yamout, M.A., Dyson, H.J., Wright, P.E. J. Mol. Biol. (2000)
- Application of a fluorescent histone acetyltransferase assay to probe the substrate specificity of the human p300/CBP-associated factor. Trievel, R.C., Li, F.Y., Marmorstein, R. Anal. Biochem. (2000)
- Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex. Zegerman, P., Canas, B., Pappin, D., Kouzarides, T. J. Biol. Chem. (2002)
- Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5. Wiper-Bergeron, N., Salem, H.A., Tomlinson, J.J., Wu, D., Haché, R.J. Proc. Natl. Acad. Sci. U.S.A. (2007)
- The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. Gangisetty, O., Lauffart, B., Sondarva, G.V., Chelsea, D.M., Still, I.H. Oncogene (2004)
- GCN5 and ADA adaptor proteins regulate triiodothyronine/GRIP1 and SRC-1 coactivator-dependent gene activation by the human thyroid hormone receptor. Anafi, M., Yang, Y.F., Barlev, N.A., Govindan, M.V., Berger, S.L., Butt, T.R., Walfish, P.G. Mol. Endocrinol. (2000)
- c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. Liu, X., Tesfai, J., Evrard, Y.A., Dent, S.Y., Martinez, E. J. Biol. Chem. (2003)
- Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma. Kraker, A.J., Mizzen, C.A., Hartl, B.G., Miin, J., Allis, C.D., Merriman, R.L. Mol. Cancer Ther. (2003)