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DONSON  -  downstream neighbor of SON

Homo sapiens

Synonyms: B17, C21orf60, C2TA, DKFZP434M035, Protein downstream neighbor of Son
 
 
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Disease relevance of DONSON

 

High impact information on DONSON

  • Treating the cells with oleate reversed the effect of mPDI on B48 secretion in a dose-dependent manner, but had no effect on B17 [6].
  • Using kinetic analysis of the DMPC clearance assay, we show that the identified phospholipid binding sequences all map to the surface of the lipid binding pocket in the B17 model based on the homologous protein, lipovitellin [7].
  • Mutagenesis of three aspartates to alanine in these motifs (D132, D147, and D199) reduced Microcin B17 production in vivo and heterocycle formation in vitro, suggesting that the 45 kDa McbD has a regulated ATPase/GTPase domain in its N-terminal region necessary for peptide heterocyclization [1].
  • ATP/GTP hydrolysis is required for oxazole and thiazole biosynthesis in the peptide antibiotic microcin B17 [1].
  • Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes [8].
 

Biological context of DONSON

  • AW33, B17, and DR3 are in linkage disequilibrium in our normal Chinese population [9].
  • All the residues in human insulin that are considered to be important in receptor binding, dimerization, and hexamerization are conserved in lungfish insulin except for the substitution (Leu --> Phe) at the position corresponding to B17 in human insulin [10].
  • All isolates were type II by genetic characterization at five microsatellite loci (TUB2, TgM-A, W35, B17, B18) [11].
  • Microcirculatory effects of the application of an acupuncture needle (32-gauge, silver) to the back, corresponding to Geshu (B17) in human beings, were studied in vivo by microscope, using a transparent ear chamber in conscious rabbits [12].
 

Anatomical context of DONSON

  • The proportions of B17 and F6 cells in the cell line seem to be similar to the proportion of antibodies in the supernatant [13].
  • Besides non-antibody secreting cells, the line consists of two clonotypes of antibody-secreting cells: B17 cells producing over 90% and F6 cells producing less than 10% of the antibody in the supernatant [13].
  • Microvilli were most abundant in elevated nuclear regions and lateral processes were short and not as complex as those between B17 cells [14].
 

Associations of DONSON with chemical compounds

 

Other interactions of DONSON

  • The biological activity of siren insulin was not investigated in this study but the substitutions at B28 (involved in dimer formation) and at B14 and B17 (involved in hexamer formation) may be expected to influence conformation and therefore biological potency [16].
 

Analytical, diagnostic and therapeutic context of DONSON

  • Dissection 72 hr post-injection demonstrated that BpAb B17/CE25 and BpAb F6/B17 gave higher tumor uptake than that of their parental F(ab')2 [17].
  • Recovery of B17P from stoma fluid samples was significantly lower for formulation III than for formulations I and II [15].
  • The frequency of B17 was higher in both patient groups than in a control group of healthy individuals [18].

References

  1. ATP/GTP hydrolysis is required for oxazole and thiazole biosynthesis in the peptide antibiotic microcin B17. Milne, J.C., Eliot, A.C., Kelleher, N.L., Walsh, C.T. Biochemistry (1998) [Pubmed]
  2. Cytokeratin in anaplastic large cell lymphoma. Frierson, H.F., Bellafiore, F.J., Gaffey, M.J., McCary, W.S., Innes, D.J., Williams, M.E. Mod. Pathol. (1994) [Pubmed]
  3. Sacroiliitis in the Old Order Amish. Arnett, F.C., Enlow, R.W., Bias, W.B. Am. J. Med. Genet. (1982) [Pubmed]
  4. Signal sequence-independent protein secretion in gram-negative bacteria: colicin V and microcin B17. Skvirsky, R.C., Gilson, L., Kolter, R. Methods Cell Biol. (1991) [Pubmed]
  5. HLA and cancer in South African Indians. Hammond, M.G., Appadoo, B., Brain, P. Tissue Antigens (1979) [Pubmed]
  6. The enzymatic and non-enzymatic roles of protein-disulfide isomerase in apolipoprotein B secretion. Wang, L., Fast, D.G., Attie, A.D. J. Biol. Chem. (1997) [Pubmed]
  7. Defining lipid-interacting domains in the N-terminal region of apolipoprotein B. Jiang, Z.G., Gantz, D., Bullitt, E., McKnight, C.J. Biochemistry (2006) [Pubmed]
  8. Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes. Wynn, S.L., Fisher, R.A., Pagel, C., Price, M., Liu, Q.Y., Khan, I.M., Zammit, P., Dadrah, K., Mazrani, W., Kessling, A., Lee, J.S., Buluwela, L. Genomics (2000) [Pubmed]
  9. HLA-system in Chinese children with insulin-dependent diabetes mellitus: a strong association with DR3. Lee, B.W., Chan, S.H., Tan, S.H., Wee, G.B., Yap, H.K., Wong, H.B., Tan, C.L., Tan, K.W. Metab. Clin. Exp. (1984) [Pubmed]
  10. Purification and characterization of insulin from the Australian lungfish, Neoceratodus forsteri (Dipnoi). Conlon, J.M., Basir, Y., Joss, J.M. Gen. Comp. Endocrinol. (1999) [Pubmed]
  11. Toxoplasma gondii infection in sheep from Haute-Vienne, France: Seroprevalence and isolate genotyping by microsatellite analysis. Dum??tre, A., Ajzenberg, D., Rozette, L., Mercier, A., Dard??, M.L. Vet. Parasitol. (2006) [Pubmed]
  12. Effects of acupuncture needle application upon cutaneous microcirculation of rabbit ear lobe. Itaya, K., Manaka, Y., Ohkubo, C., Asano, M. Acupuncture & electro-therapeutics research. (1987) [Pubmed]
  13. Clonal analysis of a human lymphoblastoid cell line (B17) secreting antibody to N-acetyl-D-glucosamine. Polke, C., Greger, B., Steinitz, M., Eichmann, K. Immunobiology (1982) [Pubmed]
  14. Surface features of three human cell lines established from diagnostic biopsies of esophageal carcinomas. Robinson, K.M., Evers, P., Maistry, L. Scanning electron microscopy. (1983) [Pubmed]
  15. The gastrointestinal passage and release of beclomethasone dipropionate from oral delivery systems in ileostomy volunteers. Burggraaf, J., van Haarst, A.D., Fockens, P., Schoemaker, H.C., Krauwinkel, W.J., Cohen, A.F. British journal of clinical pharmacology. (1998) [Pubmed]
  16. Purification and structural characterization of insulin from the lesser siren, Siren intermedia (Amphibia: Caudata). Conlon, J.M., Trauth, S.E., Sever, D.M. Gen. Comp. Endocrinol. (1997) [Pubmed]
  17. Tumor targeting with newly designed biparatopic antibodies directed against two different epitopes of the carcinoembryonic antigen (CEA). Robert, B., Dorvillius, M., Buchegger, F., Garambois, V., Mani, J.C., Pugnières, M., Mach, J.P., Pèlegrin, A. Int. J. Cancer (1999) [Pubmed]
  18. Frequency of HLA antigens in patients with psoriasis or psoriatic arthritis. McKendry, R.J., Sengar, D.P., DesGroseilliers, J.P., Dunne, J.V. Canadian Medical Association journal. (1984) [Pubmed]
 
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