Disease relevance of BCL2L1

• To characterize the molecular events involved in both apoptosis and transformation process induced by Marek's disease virus (MDV), the expressions of the bcl-2 and bcl-x genes, ones of the dominant apoptosis-regulating genes, in Marek's disease (MD) tumor cell lines and cells prepared from MDV-infected chickens were analyzed [1].

High impact information on BCL2L1

• Together these data suggest that bcl-x plays an important role in both positive and negative regulation of programmed cell death [2].
• bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death [2].
• Alternative splicing results in two distinct bcl-x mRNAs [2].
• The proto-oncogene bcl-2, isolated from the t(14;18) chromosomal breakpoint in follicular B-lymphoma, and a bcl-2-related gene bcl-x (ref. 4) prevent apoptotic cell death induced by various treatments [3].
• Differential expression of bcl-2 and bcl-x during chicken spermatogenesis [4].

Biological context of BCL2L1

• In addition, we also showed that CD28 can give a costimulatory signal to gammadelta T cells and that this signal leads to up-regulation of IL-2 and bcl-x transcripts [5].

Anatomical context of BCL2L1

• Differential expression of bcl-2 and bcl-x during spermatogenesis is consistent with the reported different susceptibility to apoptosis of spermatogonia, and meiotic and postmeiotic cells [4].
• We report the isolation and characterization of a chicken testis bcl-XL cDNA coding for a long bcl-x protein with a hydrophobic tail, and the expression of bcl-2 and bcl-x during chicken spermatogenesis [4].
• Expression of bcl-2 and bcl-x genes in lymphocytes and tumor cell lines derived from MDV-infected chickens [1].

References